Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Mar 26;20(6):1505.
doi: 10.3390/ijms20061505.

Associations between Adipokines in Arthritic Disease and Implications for Obesity

Iona J MᵃᶜDonald  1 , Shan-Chi Liu  2   3 , Chien-Chung Huang  4   5 , Shu-Jui Kuo  6   7 , Chun-Hao Tsai  8   9 , Chih-Hsin Tang  10   11   12   13
Affiliations
Review

Associations between Adipokines in Arthritic Disease and Implications for Obesity

Iona J MᵃᶜDonald et al. Int J Mol Sci. .

Abstract

Secretion from adipose tissue of adipokines or adipocytokines, comprising of bioactive peptides or proteins, immune molecules and inflammatory mediators, exert critical roles in inflammatory arthritis and obesity. This review considers the evidence generated over the last decade regarding the effects of several adipokines including leptin, adiponectin, visfatin, resistin, chemerin and apelin, in cartilage and bone homeostasis in the pathogenesis of rheumatoid arthritis and osteoarthritis, which has important implications for obesity.

Keywords: adipokines; obesity; osteoarthritis; rheumatoid arthritis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The important role of adipokines. Adipokines are produced mainly by adipocytes and play critical roles in several major disorders including insulin sensitivity, cardiovascular disease, arthritic conditions (i.e., RA and OA), and obesity.
Figure 2
Figure 2
Critical pathways involving adipokines in arthritic diseases. Adipose tissue paracrine signaling in RA and OA demonstrates systemic links between adipokines and arthritic disease.
See this image and copyright information in PMC

References

    1. Azamar-Llamas D., Hernandez-Molina G., Ramos-Avalos B., Furuzawa-Carballeda J. Adipokine Contribution to the Pathogenesis of Osteoarthritis. Mediat. Inflamm. 2017;2017:5468023. doi: 10.1155/2017/5468023. - DOI - PMC - PubMed
    1. Guo Q., Wang Y., Xu D., Nossent J., Pavlos N.J., Xu J. Rheumatoid arthritis: Pathological mechanisms and modern pharmacologic therapies. Bone Res. 2018;6:15. doi: 10.1038/s41413-018-0016-9. - DOI - PMC - PubMed
    1. Gremese E., Tolusso B., Gigante M.R., Ferraccioli G. Obesity as a risk and severity factor in rheumatic diseases (autoimmune chronic inflammatory diseases) Front. Immunol. 2014;5:576. doi: 10.3389/fimmu.2014.00576. - DOI - PMC - PubMed
    1. De Hair M.J., Landewe R.B., van de Sande M.G., van Schaardenburg D., van Baarsen L.G., Gerlag D.M., Tak P.P. Smoking and overweight determine the likelihood of developing rheumatoid arthritis. Ann. Rheum. Dis. 2013;72:1654–1658. doi: 10.1136/annrheumdis-2012-202254. - DOI - PMC - PubMed
    1. Mandl L.A., Costenbader K.H., Simard J.F., Karlson E.W. Is birthweight associated with risk of rheumatoid arthritis? Data from a large cohort study. Ann. Rheum. Dis. 2009;68:514–518. doi: 10.1136/ard.2007.080937. - DOI - PMC - PubMed