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. 1986 Aug;49(8):853-60.
doi: 10.1136/jnnp.49.8.853.

Brain dopamine metabolism in patients with Parkinson's disease measured with positron emission tomography

K L Leenders, A J Palmer, N Quinn, J C Clark, G Firnau, E S Garnett, C Nahmias, T Jones, C D Marsden

Brain dopamine metabolism in patients with Parkinson's disease measured with positron emission tomography

K L Leenders et al. J Neurol Neurosurg Psychiatry. 1986 Aug.

Abstract

L-[18F] fluorodopa was administered in trace amounts intravenously to healthy control subjects and to patients with Parkinson's disease. Striatal uptake of radioactivity was measured using positron emission tomography. The capacity of the striatum to retain tracer was severely impaired in patients compared to controls. This may reflect a reduction of striatal dopamine storage in Parkinson's disease. Patients showing the "on/off" phenomenon had an even greater decrease of striatal storage capacity.

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