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. 1986 Sep;27(9):1462-6.

Routine synthesis of L-[18F]6-fluorodopa with fluorine-18 acetyl hypofluorite

M J Adam, T J Ruth, J R Grierson, B Abeysekera, B D Pate
  • PMID: 3091786
Free article

Routine synthesis of L-[18F]6-fluorodopa with fluorine-18 acetyl hypofluorite

M J Adam et al. J Nucl Med. 1986 Sep.
Free article

Abstract

The synthesis of L-[18F]6-fluorodopa (2.4-10.6 mCi) was done by passing gaseous [18F]acetyl hypofluorite through a solution of L-methyl-N- acetyl-[beta-(3-methoxy-4-acetoxyphenyl)]alaninate in acetic acid at room temperature followed by the hydrolysis of the intermediate products with concentrated hydriodic acid. The desired fluorodopa isomer was isolated in 8% EOB radiochemical yield by high performance liquid chromatography in an overall synthesis time of 100 min.

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