Comment
doi: 10.1158/2159-8290.CD-NB2019-040.
Epub 2019 Mar 27.
New Agents Designed to Fight EBV+ Cancers
- PMID: 30917998
- DOI: 10.1158/2159-8290.CD-NB2019-040
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Comment
New Agents Designed to Fight EBV+ Cancers
Cancer Discov.
2019 May.
Abstract
Researchers report using structure-based design to create small molecules capable of preventing the viral protein Epstein-Barr Nuclear Antigen 1 from binding to DNA, thus blocking viral replication. The molecules inhibited the growth of tumors in cell lines and in patient-derived xenografts of Epstein-Barr virus-positive cancers.
©2019 American Association for Cancer Research.
Comment on
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Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth.Sci Transl Med. 2019 Mar 6;11(482):eaau5612. doi: 10.1126/scitranslmed.aau5612. Sci Transl Med. 2019. PMID: 30842315 Free PMC article.
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