Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1986;23(2):108-12.
doi: 10.1007/BF02099904.

The template properties of some oligodeoxynucleotides containing cytidine and guanosine

T Haertle, L E Orgel
Comparative Study

The template properties of some oligodeoxynucleotides containing cytidine and guanosine

T Haertle et al. J Mol Evol. 1986.

Abstract

The co-condensation of guanosine- and cytidine-5'-phospho-2-methylimidazolide on various oligodeoxynucleotides containing C and G has been studied. We find that GC7 is an effective template for the incorporation of C into products of the form GnC, whereas C7G does not act as a template for C incorporation. The template C3GC3GC3GC3 directs the synthesis of complementary products, but the yield of long oligomers is very small. Templates in which G residues are contiguous or separated by a single C residue are ineffective, while templates containing the sequence GCCG are very inefficient. The significance of these findings in the context of prebiotic chemistry is discussed.

PubMed Disclaimer

References

    1. J Mol Biol. 1984 Sep 25;178(3):669-76 - PubMed
    1. J Mol Biol. 1986 Apr 5;188(3):433-41 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 Feb;82(4):963-7 - PubMed
    1. J Mol Biol. 1985 Jan 20;181(2):271-9 - PubMed
    1. J Mol Biol. 1986 Mar 5;188(1):77-80 - PubMed

Publication types