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Review
. 2019 Mar 18;10(3):123-127.
doi: 10.5312/wjo.v10.i3.123.

Linkage of microbiota and osteoporosis: A mini literature review

David Yatsonsky Ii  1 , Karen Pan  1 , Vithal B Shendge  1 , Jiayong Liu  2 , Nabil A Ebraheim  1
Affiliations
Review

Linkage of microbiota and osteoporosis: A mini literature review

David Yatsonsky Ii et al. World J Orthop. .

Abstract

The gut microbiota (GM) has become a recent topic of interest in the role of many disease states. Assessing patients with osteoporosis (OP), there is a strong correlation between gut microbe dysregulation and decreased bone density. Gut dysbiosis may lead to inflammation, dysregulation of nutrient and calcium transport across the intestine into circulation and systemic inflammation. Investigation of microbial profile relative to normal gut microbiomes, assessment of inflammatory markers such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha. Therapies to normalize GM in patients with OP or prevent occurrence of OP to be investigated include: High fiber prebiotic diets to promote growth of normal gut bacteria and short chain fatty acid production, Probiotics to encourage growth of normal gut microbes, and antibiotic treatment followed by fecal matter transplant.

Keywords: Bone density; Gut microbiota; Linkage; Microbiota; Osteoporosis.

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Conflict of interest statement

Conflict-of-interest statement: The authors have no conflicts of interest to declare.

References

    1. Kanis JA, Melton LJ, 3rd, Christiansen C, Johnston CC, Khaltaev N. The diagnosis of osteoporosis. J Bone Miner Res. 1994;9:1137–1141. - PubMed
    1. Cummings SR, Kelsey JL, Nevitt MC, O'Dowd KJ. Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev. 1985;7:178–208. - PubMed
    1. Mahakala A, Thoutreddy S, Kleerekoper M. Prevention and treatment of postmenopausal osteoporosis. Treat Endocrinol. 2003;2:331–345. - PubMed
    1. Wright NC, Looker AC, Saag KG, Curtis JR, Delzell ES, Randall S, Dawson-Hughes B. The recent prevalence of osteoporosis and low bone mass in the United States based on bone mineral density at the femoral neck or lumbar spine. J Bone Miner Res. 2014;29:2520–2526. - PMC - PubMed
    1. Collins FL, Rios-Arce ND, Schepper JD, Parameswaran N, McCabe LR. The Potential of Probiotics as a Therapy for Osteoporosis. Microbiol Spectr. 2017:5. - PMC - PubMed