Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Sep 1;17(2):333-343.
doi: 10.1007/s40200-018-0349-3. eCollection 2018 Dec.

An association between IL-10 promoter polymorphisms and diabetic nephropathy: a meta-analysis of case-control studies

Cho Naing  1   2 , Norah Htet Htet #  3 , Arun Kumar Basavaraj #  3 , Sivalingam Nalliah  3
Affiliations
Review

An association between IL-10 promoter polymorphisms and diabetic nephropathy: a meta-analysis of case-control studies

Cho Naing et al. J Diabetes Metab Disord. .

Abstract

Background: This study aimed to synthesize evidence on the association between IL-10 gene (-819 C/T, -1082 A/G, -592 A/C) polymorphisms and the risk of developing diabetic nephropathy.

Methods: A systematic literature search was done in health-related electronic databases. The search was limited to studies published in English until September 2017. We also checked the references of retrieved articles and relevant reviews for any additional studies. The methodological quality of the studies included in this review was assessed using the 'Scales for Quality Assessment'. The I 2 test was used to quantify between-study heterogeneity. A value of I 2 > 50% indicated substantial heterogeneity. For the pooled analysis, summary odds ratio (OR) and its 95% confidence interval (CI) in random effect model were used.

Results: Eight case-control studies (1192 cases with diabetic nephropathy and 2399 controls) met the inclusion criteria. Three groups of people namely Africans, Asians and Caucasians were included in this review. There were significant protective effects of SNP -819 C/T in overall population (OR 0.32, 95% CI 0.26-0.4) and - 1082 A/G SNP in the Asian population (OR 0.64, 95% CI 0.47-0.86) on diabetic nephropathy in the recessive model. There was no significant effect of -592 A/C on diabetic nephropathy.

Conclusion: The findings suggest the protective effects of -1082A/G and -819G/A polymorphisms on the risk of developing diabetic nephropathy in type 2 diabetes mellitus, especially in the Asian population. Well- designed, prospective studies with sufficient number of participants are recommended to substantiate these findings.

Keywords: Association; Diabetes mellitus; Interleukin-10; Meta-analysis; Nephropathy.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent were waived by the Joint Research and Ethics Committee at the International Medical University in Kula Lumpur of Malaysia as this study was exclusively performed with the published data.Not applicable.The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Study selection flow diagram
Fig. 2
Fig. 2
Allele contrast models assessing IL-10 polymorphisms and the risk of diabetic nephropathy
Fig. 2
Fig. 2
Allele contrast models assessing IL-10 polymorphisms and the risk of diabetic nephropathy
Fig. 2
Fig. 2
Allele contrast models assessing IL-10 polymorphisms and the risk of diabetic nephropathy
Fig. 3
Fig. 3
Cumulative meta-analysis of association between −1082 A/G and the risk of diabetic nephropathy
Fig. 4
Fig. 4
Funnel plot using data from −1082 A/G in diabetic nephropathy
See this image and copyright information in PMC

References

    1. Lyssenko V, Laakso M. Genetic screening for the risk of type 2 diabetes: worthless or valuable? Diabetes Care. 2013;36:120–126. doi: 10.2337/dcS13-2009. - DOI - PMC - PubMed
    1. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001;19:683–765. doi: 10.1146/annurev.immunol.19.1.683. - DOI - PubMed
    1. Cyktor JC, Turner J. Interleukin-10 and immunity against prokaryotic and eukaryotic intracellular pathogens. Infect Immun. 2011;79:2964–2973. doi: 10.1128/IAI.00047-11. - DOI - PMC - PubMed
    1. Bijjiga E, Martino AT. Interleukin 10 (IL-10) regulatory cytokine and its clinical consequences. J Clin Cell Immunol. 2013;S1:007.
    1. Iyer SS, Cheng G. Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease. Crit Rev Immunol. 2012;32:23–63. doi: 10.1615/CritRevImmunol.v32.i1.30. - DOI - PMC - PubMed

LinkOut - more resources