Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019:1957:3-8.
doi: 10.1007/978-1-4939-9158-7_1.

A Brief History of the β-Arrestins

Marc G Caron  1   2   3 , Lawrence S Barak  4
Affiliations
Review

A Brief History of the β-Arrestins

Marc G Caron et al. Methods Mol Biol. 2019.

Abstract

Arrestins have now been implicated in the actions of virtually every G protein-coupled receptor (GPCR) for which they have been examined. Originally discovered for their role in the turnoff of visual perception, their newly discovered pleotropic functions in the cellular and physiological actions of GPCRs not only illuminate new mechanisms of signal transduction but also offer new avenues for therapeutic utility. Below, in this introductory chapter, we provide a short historical description and synopsis of how arrestins conceptually became associated with the function of GPCRs.

Keywords: Desensitization; Endocytosis; GPCR; GPCR kinases; Signaling selectivity/bias; Therapeutics; β-Arrestins.

PubMed Disclaimer

References

    1. Dorey C, Faure JP (1977) Isolation and characterization of a retinal antigen inducing experimental autoimmune uveo-retinitis. Ann Immunol (Paris) 128:229–232 - PubMed
    1. Pfister C, Chabre M, Plouet J, Tuyen VV, De Kozak Y, Faure JP, Kuhn H (1985) Retinal S antigen identified as the 48K protein regulating light-dependent phosphodiesterase in rods. Science 228:891–893 - PubMed
    1. Dixon RA, Kobilka BK, Strader DJ, Benovic JL, Dohlman HG, Frielle T, Bolanowski MA, Bennett CD, Rands E, Diehl RE, Mumford RA, Slater EE, Sigal IS, Caron MG, Lefkowitz RJ, Strader CD (1986) Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin. Nature 321:75–79 - PubMed
    1. Stadel JM, Nambi P, Lavin TN, Heald SL, Caron MG, Lefkowitz RJ (1982) Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. Structural alterations in the beta-adrenergic receptor revealed by photoaffinity labeling. J Biol Chem 257:9242–9245 - PubMed
    1. Stadel JM, Nambi P, Shorr RG, Sawyer DF, Caron MG, Lefkowitz RJ (1983) Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor. Proc Natl Acad Sci U S A 80:3173–3177 - PMC - PubMed

Publication types

LinkOut - more resources