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Meta-Analysis
. 2019 Mar 29;19(1):105.
doi: 10.1186/s12884-019-2249-z.

Maternal body mass index and risk of neonatal adverse outcomes in China: a systematic review and meta-analysis

Lei Liu  1 , Yanan Ma  2 , Ningning Wang  1 , Wenjing Lin  1 , Yang Liu  2 , Deliang Wen  3
Affiliations
Meta-Analysis

Maternal body mass index and risk of neonatal adverse outcomes in China: a systematic review and meta-analysis

Lei Liu et al. BMC Pregnancy Childbirth. .

Abstract

Background: Maternal body mass index is linked to short- and long-term unfavorable health outcomes both for child and mother. We conducted a systematic review and meta-analysis of population-based cohort studies to evaluate maternal BMI and the risk of harmful neonatal outcomes in China.

Methods: Six databases identified 2454 articles; 46 met the inclusion criteria for this study. The dichotomous data on maternal BMI and harmful neonatal outcomes were extracted. Pooled statistics (odds ratios, ORs) were derived from Stata/SE, ver. 12.0. Sensitivity analyses assessed the robustness of the results. Meta-regression and subgroup meta-analyses explored heterogeneity.

Results: The meta-analysis revealed that compared with normal BMI, high maternal BMI is associated with fetal overgrowth, defined as macrosomia ≥4000 g (OR 1.91, 95% CI 1.75-2.09); birth weight ≥ 90% for gestational age (OR 1.88, 95% CI 1.64-2.15); and increased risk of premature birth (OR 1.38, 95% CI 1.25-2.52) and neonatal asphyxia (OR 1.74, 95% CI 1.39-2.17). Maternal underweight increased the risk of low birth weight (OR 1.61, 95% CI 1.33-1.93) and small for gestational age (OR 1.75, 95% CI 1.51-2.02).

Conclusions: Raised as well as low pre-pregnancy BMI is associated with adverse neonatal outcomes. Management of weight during pregnancy might help reduce their adverse neonatal outcomes in future intervention studies or programmes.

Keywords: Cohort study; Maternal BMI; Meta-analysis; Neonatal outcomes.

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Competing interests

The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
Flow diagram of the systematic selection of articles for the meta-analysis (based on PRISMA reporting)
See this image and copyright information in PMC

References

    1. Livingston EH. Reimagining obesity in 2018: a JAMA theme issue on obesity. JAMA. 2018;319(3):238–240. - PubMed
    1. Collaborators TGO. Health Effects of Overweight and Obesity in 195 Countries over 25 Years New Engl J Med. 2017;377(1):13–27. - PMC - PubMed
    1. Tsoi E, Shaikh H, Robinson S, Teoh TG. Obesity in pregnancy: a major healthcare issue. Postgrad Med J. 2010;86(1020):617–623. - PubMed
    1. Poston L, Caleyachetty R, Cnattingius S, Corvalan C, Uauy R, Herring S, et al. Preconceptional and maternal obesity: epidemiology and health consequences. Lancet DiabetesI Endo. 2016;4(12):1025–1036. - PubMed
    1. Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA. 2012;307(5):491–497. - PubMed