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. 2019 Mar 28;20(1):186.
doi: 10.1186/s13063-019-3282-y.

Wound Healing In Surgery for Trauma (WHIST): statistical analysis plan for a randomised controlled trial comparing standard wound management with negative pressure wound therapy

Ruth Knight  1 , Louise M Spoors  2 , Matthew L Costa  2 , Susan J Dutton  3
Affiliations

Wound Healing In Surgery for Trauma (WHIST): statistical analysis plan for a randomised controlled trial comparing standard wound management with negative pressure wound therapy

Ruth Knight et al. Trials. .

Abstract

Background: In the context of major trauma, the rate of wound infection in surgical incisions created during fracture fixation amongst patients with closed high-energy injuries is high. One of the factors which may reduce the risk of surgical site infection is the type of dressing applied over the closed incision. The WHIST trial evaluates the effects of negative-pressure wound therapy (NPWT) compared with standard dressings.

Methods/design: The WHIST trial is a multicentre, parallel group, randomised controlled trial. The primary outcome is the rate of deep surgical site infection at 30 days after major trauma. Secondary outcomes are measured at 3 and 6 months post-randomisation and include the Disability Rating Index, the EuroQoL EQ-5D-5 L, the Doleur Neuropathique Questionnaire, a patient-reported scar assessment, and record of complications. The analysis approaches for the primary and secondary outcomes are described here, as are the descriptive statistics which will be reported. The full WHIST protocol has already been published.

Discussion: This paper provides details of the planned statistical analyses for this trial and will reduce the risks of outcome reporting bias and data driven results.

Trial registration: International Standard Randomised Controlled Trials database, ISRCTN12702354 . Registered on 9 December 2015.

Keywords: Lower extremity trauma; Negative pressure wound therapy; Randomised controlled trial; Statistical analysis plan; Surgical site infection.

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Conflict of interest statement

Ethics approval and consent to participate

This study was approved by the Research Ethic Committee on 16th February 2016 (reference 16/WM/0006). The University of Oxford is the sponsor. The trial is registered with the International Standard Randomised Controlled Trials database ISRCTN reference number 12702354.

Consent for publication

Not applicable.

Competing interests

MC is a member of the UK NIHR HTA General Board. All other authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
CONSORT flow diagram for participants in trial up to 6 months follow-up
See this image and copyright information in PMC

References

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