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Review
. 2019 Mar 29;10(1):111.
doi: 10.1186/s13287-019-1212-2.

Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies

Azar Nourian Dehkordi  1 , Fatemeh Mirahmadi Babaheydari  2 , Mohammad Chehelgerdi  3 , Shiva Raeisi Dehkordi  4
Affiliations
Review

Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies

Azar Nourian Dehkordi et al. Stem Cell Res Ther. .

Abstract

Normal wound healing is a dynamic and complex multiple phase process involving coordinated interactions between growth factors, cytokines, chemokines, and various cells. Any failure in these phases may lead wounds to become chronic and have abnormal scar formation. Chronic wounds affect patients' quality of life, since they require repetitive treatments and incur considerable medical costs. Thus, much effort has been focused on developing novel therapeutic approaches for wound treatment. Stem-cell-based therapeutic strategies have been proposed to treat these wounds. They have shown considerable potential for improving the rate and quality of wound healing and regenerating the skin. However, there are many challenges for using stem cells in skin regeneration. In this review, we present some sets of the data published on using embryonic stem cells, induced pluripotent stem cells, and adult stem cells in healing wounds. Additionally, we will discuss the different angles whereby these cells can contribute to their unique features and show the current drawbacks.

Keywords: Chronic wounds; Cytokines; Growth factors; Skin; Stem cells; Wound healing.

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Conflict of interest statement

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Not applicable.

Competing interests

The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
The function of MSCs used in innate and adaptive immune systems
Fig. 2
Fig. 2
Biological function of MSCs in soluble factor secreted
See this image and copyright information in PMC

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