Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage

Huimin Zhu¹, Zhiqiang Wang², Jixu Yu³, Xiuli Yang⁴, Feng He¹, Zhenchuan Liu⁵, Fengyuan Che⁶, Xuemei Chen⁷, Honglei Ren⁴, Michael Hong⁴, Jian Wang⁸

Affiliations

¹ Department of Neurology, Linyi People's Hospital, Linyi, Shandong 276003, China.
² Central laboratory, Linyi People's Hospital, Linyi, Shandong 276003, China.
³ Department of Neurology, Linyi People's Hospital, Linyi, Shandong 276003, China; Central laboratory, Linyi People's Hospital, Linyi, Shandong 276003, China; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.
⁴ Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
⁵ Department of Neurology, Linyi People's Hospital, Linyi, Shandong 276003, China. Electronic address: lzhenchuan@sohu.com.
⁶ Department of Neurology, Linyi People's Hospital, Linyi, Shandong 276003, China; Central laboratory, Linyi People's Hospital, Linyi, Shandong 276003, China. Electronic address: che1971@126.com.
⁷ Department of Anatomy, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, Henan, China.
⁸ Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: jwang79@jhmi.edu.

PMID: 30923023
DOI: 10.1016/j.pneurobio.2019.03.003

Review

Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage

Huimin Zhu et al. Prog Neurobiol. 2019 Jul.

. 2019 Jul:178:101610.

doi: 10.1016/j.pneurobio.2019.03.003. Epub 2019 Mar 25.

Authors

Huimin Zhu¹, Zhiqiang Wang², Jixu Yu³, Xiuli Yang⁴, Feng He¹, Zhenchuan Liu⁵, Fengyuan Che⁶, Xuemei Chen⁷, Honglei Ren⁴, Michael Hong⁴, Jian Wang⁸

Affiliations

¹ Department of Neurology, Linyi People's Hospital, Linyi, Shandong 276003, China.
² Central laboratory, Linyi People's Hospital, Linyi, Shandong 276003, China.
³ Department of Neurology, Linyi People's Hospital, Linyi, Shandong 276003, China; Central laboratory, Linyi People's Hospital, Linyi, Shandong 276003, China; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.
⁴ Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
⁵ Department of Neurology, Linyi People's Hospital, Linyi, Shandong 276003, China. Electronic address: lzhenchuan@sohu.com.
⁶ Department of Neurology, Linyi People's Hospital, Linyi, Shandong 276003, China; Central laboratory, Linyi People's Hospital, Linyi, Shandong 276003, China. Electronic address: che1971@126.com.
⁷ Department of Anatomy, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, Henan, China.
⁸ Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: jwang79@jhmi.edu.

PMID: 30923023
DOI: 10.1016/j.pneurobio.2019.03.003

Abstract

Intracerebral hemorrhage (ICH) is a common and severe cerebrovascular disease that has high mortality. Few survivors achieve self-care. Currently, patients receive only symptomatic treatment for ICH and benefit poorly from this regimen. Inflammatory cytokines are important participants in secondary injury after ICH. Increases in proinflammatory cytokines may aggravate the tissue injury, whereas increases in anti-inflammatory cytokines might be protective in the ICH brain. Inflammatory cytokines have been studied as therapeutic targets in a variety of acute and chronic brain diseases; however, studies on ICH are limited. This review summarizes the roles and functions of various pro- and anti-inflammatory cytokines in secondary brain injury after ICH and discusses pathogenic mechanisms and emerging therapeutic strategies and directions for treatment of ICH.

Keywords: Cytokines; ICH; Inflammatory reaction; Secondary injury.

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Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage

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Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage

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