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Comment
. 2019 May 6;216(5):1010-1011.
doi: 10.1084/jem.20190246. Epub 2019 Mar 28.

The Aire family expands

Adrian Liston  1 , James Dooley  2
Affiliations
Comment

The Aire family expands

Adrian Liston et al. J Exp Med. .

Abstract

T cell tolerance depends upon Aire-expressing cells to purge the T cell repertoire of autoreactive clones. Once thought to be the exclusive domain of thymic epithelial cells, a new study by Yamano et al. (https://doi.org/10.1084/jem.20181430) in this issue of JEM identifies ILC3-like cells in the lymph nodes with similar properties.

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Figures

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Insights from Adrian Liston and James Dooley.
See this image and copyright information in PMC

Comment on

  • Aire-expressing ILC3-like cells in the lymph node display potent APC features.
    Yamano T, Dobeš J, Vobořil M, Steinert M, Brabec T, Ziętara N, Dobešová M, Ohnmacht C, Laan M, Peterson P, Benes V, Sedláček R, Hanayama R, Kolář M, Klein L, Filipp D. Yamano T, et al. J Exp Med. 2019 May 6;216(5):1027-1037. doi: 10.1084/jem.20181430. Epub 2019 Mar 27. J Exp Med. 2019. PMID: 30918005 Free PMC article.

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