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Case Reports
. 2019 Apr 9;3(7):952-955.
doi: 10.1182/bloodadvances.2019032300.

Leukemoid reaction in chronic myelomonocytic leukemia patients undergoing surgery: perioperative management recommendations

Ami B Patel  1 , Erin M Pettijohn  2 , Sameem M Abedin  3 , Evan Raps  4 , Michael W Deininger  1
Affiliations
Case Reports

Leukemoid reaction in chronic myelomonocytic leukemia patients undergoing surgery: perioperative management recommendations

Ami B Patel et al. Blood Adv. .

Abstract

  1. CMML patients comprise an elderly and frail patient population with comorbidities that often require surgical intervention.

  2. Postsurgical leukemoid reaction, a life-threatening complication in CMML patients, may be driven by molecular mechanisms.

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Conflict of interest statement

Conflict-of-interest disclosure: M.W.D. reports research funding from, and is a paid advisory board member and/or consultant for, the following companies: Blueprint; Pfizer, Inc; Takeda; Ascentage Pharma; Aptitude Health; and Humana. The remaining authors declare no competing financial interests.

Figures

Figure 1.
Figure 1.
Multiorgan leukostasis (case 1). Hematoxylin and eosin–stained sections (original magnification ×20) taken from autopsy showed severe diffuse leukostasis in the brain (A), heart (B), lungs (C), and spinal cord (D). Additionally, the spleen, liver, colon, and uterus displayed similar findings with evidence of ischemia and end-organ damage (not shown).
See this image and copyright information in PMC

References

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