Conflict of interest: J.A. Mackintosh has nothing to disclose. Conflict of interest: S.R. Desai reports personal fees from Boehringer Ingelheim, outside the submitted work. Conflict of interest: H. Adamali has nothing to disclose. Conflict of interest: K. Patel has nothing to disclose. Conflict of interest: F. Chua has nothing to disclose. Conflict of interest: A. Devaraj has nothing to disclose. Conflict of interest: V. Kouranos has nothing to disclose. Conflict of interest: M. Kokosi has nothing to disclose. Conflict of interest: G. Margaritopoulos has nothing to disclose. Conflict of interest: E.A. Renzoni reports lecture fees and advisory board fees from Boeringher Ingelheim and Roche, and lecture fees from Mundipharma, outside the submitted work. Conflict of interest: A.U. Wells reports personal fees for lecturing and advisory board work from Boehringer Ingelheim, Roche and Bayer, outside the submitted work. Conflict of interest: P.L. Molyneaux has, via his institution, received consultancy or speaker fees from Boehringer Ingelheim and Roche. Conflict of interest: S. Kumar has nothing to disclose. Conflict of interest: T.M. Maher reports grants and personal fees from GSK, grants, personal fees and non-financial support from UCB, personal fees and research fees from AstraZeneca, personal fees from Boehringer Ingelheim, Roche, Bayer, Biogen Idec, Prometic, Samumed, Galapagos, Celgene, Indalo and Pliant, stock options from Apellis, outside the submitted work. Conflict of interest: P.M. George reports personal fees and non-financial support from Roche Pharmaceuticals and Boehringer Ingelheim, outside the submitted work.