Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Apr 17;25(22):5664-5667.
doi: 10.1002/chem.201900591. Epub 2019 Mar 29.

Stachyonic Acid: A Dengue Virus Inhibitor from Basilicum polystachyon

Yuen P Tan  1 , Sevan D Houston  1 , Naphak Modhiran  2 , Andrei I Savchenko  1 , Glen M Boyle  3 , Paul R Young  1   2 , Daniel Watterson  1   2 , Craig M Williams  1
Affiliations

Stachyonic Acid: A Dengue Virus Inhibitor from Basilicum polystachyon

Yuen P Tan et al. Chemistry. .

Abstract

Stachyonic acid A, arising from the first in-depth phytochemical investigation of the herb Basilicum polystachyon, was found to display potent inhibitory activity against dengue virus, with limited cytotoxicity. Andrographolide, a known dengue virus inhibitor and closely related labdane-type diterpene, is structurally more complex but displayed poor antiviral activity in the PRNT assay, and increased cytotoxicity in comparison. Furthermore, a Diels-Alder reaction with PTAD identified the active pharmacophore of stachyonic acid to be the conjugated diene.

Keywords: basilicum; dengue; labdane; natural products; viruses.

PubMed Disclaimer

LinkOut - more resources