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Comment
. 2019 Jul;108(7):1190-1191.
doi: 10.1111/apa.14800. Epub 2019 Apr 11.

Why results from Bayesian statistical analyses of clinical trials with a strong prior and small sample sizes may be misleading The case of the NICHD Neonatal Research Network Late Hypothermia Trial

Lars Walløe  1 , Nils Lid Hjort  2 , Marianne Thoresen  1   3
Affiliations
Comment

Why results from Bayesian statistical analyses of clinical trials with a strong prior and small sample sizes may be misleading The case of the NICHD Neonatal Research Network Late Hypothermia Trial

Lars Walløe et al. Acta Paediatr. 2019 Jul.
No abstract available

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Conflict of interest statement

The authors have no conflict of interests.

Figures

Figure 1
Figure 1
Red curve: The neutral prior probability distribution from Laptook et al. 3 with median rr = 1.0. The distribution is normal in log space with SD = 0.35. Solid black curve: Posterior distribution calculated from the prior and the results from the trial. Dashed black curve: Posterior distribution calculated from the hypothetical results were two infants with adverse outcome were moved from the non‐cooled group to the cooled group as a sensitivity test.
See this image and copyright information in PMC

Comment on

References

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    1. Walløe L, Hjort NL, Thoresen M. Major concerns about late hypothermia study. Acta Paediatr 2019; 108: 588–9. - PMC - PubMed
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