Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jul;19(7):448-456.
doi: 10.1038/s41577-019-0155-2.

Genome organization in immune cells: unique challenges

Timothy M Johanson  1   2 , Wing Fuk Chan  3   4 , Christine R Keenan  3   4 , Rhys S Allan  5   6
Affiliations
Review

Genome organization in immune cells: unique challenges

Timothy M Johanson et al. Nat Rev Immunol. 2019 Jul.

Abstract

Each type of cell in the immune system performs critical functions to protect the body and maintain health. In order to fulfil these roles some immune cells rely on unique processes, including antigen receptor loci recombination, clonal expansion or the contortion of their nuclei. In turn, each of these processes relies on, or poses unique challenges to, a genome organized in three dimensions. Here, we explore the current understanding of the importance of 3D genome organization in the function and development of a healthy immune system.

PubMed Disclaimer

References

    1. Bulger, M. & Groudine, M. Looping versus linking: toward a model for long-distance gene activation. Genes Dev. 13, 2465–2477 (1999). - PubMed
    1. Tolhuis, B., Palstra, R. J., Splinter, E., Grosveld, F. & de Laat, W. Looping and interaction between hypersensitive sites in the active beta-globin locus. Mol. Cell 10, 1453–1465 (2002). This study shows that DNA loops are important in the regulation of β-globin gene expression. - PubMed
    1. Song, S.-H., Hou, C. & Dean, A. A positive role for NLI/Ldb1 in long range β-globin locus control region function. Mol. Cell 28, 810–822 (2007). - PubMed - PMC
    1. Drissen, R. et al. The active spatial organization of the beta-globin locus requires the transcription factor EKLF. Genes Dev. 18, 2485–2490 (2004). - PubMed - PMC
    1. Vakoc, C. R. et al. Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1. Mol. Cell 17, 453–462 (2005). - PubMed

Publication types

Substances

LinkOut - more resources