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Review
. 2020 Jul;598(14):3005-3014.
doi: 10.1113/JP276745. Epub 2019 Apr 23.

Drugging transcription in heart failure

Arun Padmanabhan  1   2 , Saptarsi M Haldar  1   2   3
Affiliations
Free article
Review

Drugging transcription in heart failure

Arun Padmanabhan et al. J Physiol. 2020 Jul.
Free article

Abstract

Advances in our understanding of the basic biology and biochemistry of chromatin structure and function at genome scales has led to tremendous growth in the fields of epigenomics and transcriptional biology. While it has long been appreciated that transcriptional pathways are dysregulated in failing hearts, only recently has the idea of disrupting altered transcription by targeting chromatin-associated proteins been explored. Here, we provide a brief overview of efforts to drug transcription in the context of heart failure, focusing on the bromo- and extra-terminal domain (BET) family of chromatin co-activator proteins.

Keywords: cardiac hypertrophy; cardiovascular biology; chromatin; epigenetics; fibrosis; gene regulation; heart failure; transcription.

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