Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jun:68:24-29.
doi: 10.1016/j.clinbiochem.2019.03.015. Epub 2019 Mar 28.

Biomarker panel in sleep apnea patients after an acute coronary event

Josep Miquel Bauça  1 , Antonia Barcelo  2 , Laura Fueyo  3 , Pilar Sanchís  4 , Javier Pierola  4 , Monica de la Peña  5 , Meritxell Arqué  4 , Cristina Gómez  3 , Daniel Morell-Garcia  6 , Alicia Sánchez-de-la-Torre  7 , Manuel Sánchez-de-la-Torre  7 , Jorge Abad  8 , Joaquín Duran-Cantolla  9 , Olga Mediano  10 , Maria Jose Masdeu  11 , Amaia Urrutia-Gajate  12 , Juan Fernando Masa  13 , Ferran Barbé  7 ; Spanish Sleep Group
Affiliations

Biomarker panel in sleep apnea patients after an acute coronary event

Josep Miquel Bauça et al. Clin Biochem. 2019 Jun.

Abstract

Background: Acute coronary syndrome (ACS) is a major cause of death and closely related with obstructive sleep apnea (OSA). Our hypothesis is that several cardiovascular-related biomarkers could have a differential prognostic value for ACS severity in patients with OSA, and could also help (individually or combined) in the detection of OSA in patients after a coronary event.

Methods: Up to 361 consecutive individuals admitted due to ACS were included in the study. All of them were evaluated for ACS severity (Killip score, number of diseased vessels, ejection fraction) and further classified as OSA or non-OSA. Medical records were registered and eleven blood biomarkers were measured, including heart-type fatty acid-binding globulin, N-terminal pro-brain natriuretic peptide, matrix metalloproteinase-9 (MMP9), placental growth factor (PlGF) and high-sensitivity C-reactive protein. Odds ratios of every biomarker for ACS severity-related parameters were calculated and adjusted for age, gender, body-mass index (BMI), hypertension, diabetes, smoking and drinking. The use of clinical measures and biomarkers for the diagnosis of OSA in ACS patients was evaluated both alone and combined using ROC curves.

Results: Several biomarkers showed a significant association with ACS severity, which remained after adjusting for OSA and other potentially confounding variables. The mathematical combination of age, BMI, PlGF and MMP9 showed an area under the ROC curve (AUC) for OSA identification of 0.741, which was greater than any individual parameter or combination assessed: AUC(BMI):0.687, AUC(age):0.576, AUC(PlGF):0.584, AUC(MMP9):0.555.

Conclusions: The usefulness of biomarkers in the assessment of ACS severity was independent of OSA and the other variables evaluated. In patients admitted after a coronary event, the combination of clinical measures and biomarkers showed a significant discriminating power for the detection of OSA.

Clinical trial registration: NCT01335087 (clinicaltrials.gov).

Keywords: Angiogenesis; Cardiovascular risk; Diagnostic algorithm; Myocardial infarction.

PubMed Disclaimer

Associated data