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Comment
. 2019 Jun;36(6):1243-1245.
doi: 10.1007/s12325-019-00937-2. Epub 2019 Mar 30.

Response to "A Rigorous Evaluation of Methoxyflurane is Needed: Comment on 'Methoxyflurane Versus Standard of Care for Acute Trauma-Related Pain in the Emergency Setting: Protocol for a Randomised, Controlled Study in Italy (MEDITA)'"

Andrea Fabbri  1 , Giuseppe Carpinteri  2 , Germana Ruggiano  3 , Elisabetta Bonafede  4 , Antonella Sblendido  5 , Alberto Farina  6 , Amedeo Soldi  5
Affiliations
Comment

Response to "A Rigorous Evaluation of Methoxyflurane is Needed: Comment on 'Methoxyflurane Versus Standard of Care for Acute Trauma-Related Pain in the Emergency Setting: Protocol for a Randomised, Controlled Study in Italy (MEDITA)'"

Andrea Fabbri et al. Adv Ther. 2019 Jun.
No abstract available

Keywords: Acute pain; Analgesic; Emergency department; Inhaled analgesic; Injury; Methoxyflurane; Penthrox; Pre-hospital; Trauma.

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References

    1. Fabbri A, Carpinteri G, Ruggiano G, Bonafede E, Sblendido A, Farina A, Soldi A, MEDITA Study Group Methoxyflurane versus standard of care for acute trauma-related pain in the emergency setting: protocol for a randomised, controlled study in Italy (MEDITA) Adv Ther. 2019;36(1):244–256. doi: 10.1007/s12325-018-0830-x. - DOI - PMC - PubMed
    1. Coffey F, Wright J, Hartshorn S, Hunt P, Locker T, Mirza K, Dissmann P. STOP!: a randomised, double-blind, placebo-controlled study of the efficacy and safety of methoxyflurane for the treatment of acute pain. Emerg Med J. 2014;31(8):613–618. doi: 10.1136/emermed-2013-202909. - DOI - PMC - PubMed
    1. Borobia Pe´rez AM, Capilla Pueyo R, Casal Codesido JR, InMEDIATE Group et al. Phase IIIb, open label randomised clinical trial to compare pain relief between methoxyflurane and standard of care for treating patients with trauma pain in Spanish Emergency Units (InMEDIATE): study protocol. IBJ Clin Pharmacol. 2017;1:e0008.
    1. Borobia Pérez A, García Collado S, Carballo Cardona C, Capilla Pueyo R, Fernández Alonso C, Pérez Torres I, et al. InMEDIATE: results of a phase IIIB, open label randomised clinical trial to compare pain relief between methoxyflurane and standard of care analgesia for treating patients with trauma pain in Spanish emergency departments. Basic Clin Pharmacol Toxicol. 2018;123(Suppl. 4):16.
    1. Efficacy and Safety of Penthrox® Combined With a Standard Analgesia (SoC) in Adult Patients Admitted to the Emergency Department With Moderate to Severe Pain Associated With Trauma (Pen ASAP). NCT03798899. https://clinicaltrials.gov/ct2/show/NCT03798899?term=methoxyflurane&rank=8. Accessed 26 Feb 2019.

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