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Review
. 2019 Jun;27(6):477-479.
doi: 10.1016/j.tim.2019.03.001. Epub 2019 Mar 29.

Influenza Neuraminidase: Underrated Role in Receptor Binding

Feng Wen  1 , Xiu-Feng Wan  2
Affiliations
Review

Influenza Neuraminidase: Underrated Role in Receptor Binding

Feng Wen et al. Trends Microbiol. 2019 Jun.

Abstract

Influenza virus neuraminidase cleaves sialic acid groups from cell glycoproteins, enabling release of the virus from host cells. Neuraminidase also contributes to virus binding to the sialic acid groups of cell glycoproteins, which could complement the receptor-binding function of hemagglutinin, enhancing enzymatic activities of neuraminidase, and facilitate virus infection.

Keywords: influenza A virus; influenza virus; neuraminidase; receptor; receptor binding; sialic acids.

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