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. 2019 Mar;35(2):118-125.
doi: 10.6515/ACS.201903_35(2).20181009A.

Non-Alcoholic Fatty Pancreas Disease is Associated with Increased Epicardial Adipose Tissue and Aortic Intima-Media Thickness

Selim Kul  1 , Ayşegül Karadeniz  2 , İhsan Dursun  1 , Sinan Şahin  1 , Ömer Faruk Çırakoğlu  1 , Muhammet Raşit Sayın  1 , Turhan Turan  1 , Ahmet Hakan Ateş  3
Affiliations

Non-Alcoholic Fatty Pancreas Disease is Associated with Increased Epicardial Adipose Tissue and Aortic Intima-Media Thickness

Selim Kul et al. Acta Cardiol Sin. 2019 Mar.

Abstract

Background: We aimed to investigate whether non-alcoholic fatty pancreas disease (NAFPD) is associated with epicardial adipose tissue (EAT), which is a kind of ectopic fat accumulation, and aortic intima-media thickness (aIMT), which is associated with subclinical atherosclerosis.

Methods: Fifty-four patients with NAFPD (22 men; mean age: 52 ± 10 years) and 49 without NAFPD (16 men; mean age: 49 ± 8 years) were included in this study. NAFPD and aIMT were evaluated using transabdominal ultrasonography (TUS). EAT was evaluated with transthoracic echocardiography.

Results: EAT (6.09 ± 1.52 mm and 3.87 ± 1.31 mm, p < 0.001) and aIMT [1.12 (0.60-1.90) mm vs. 0.93 (0.50-1.44) mm, p < 0.001] were significantly higher in the NAFPD positive subjects, compared to the NAFPD negative subjects. Multivariate analysis showed that age (p = 0.016), body mass index (p = 0.004), and presence of NAFPD (p = 0.024) were associated with increased aIMT. In addition, multivariate analysis demonstrated that the presence of NAFPD (p < 0.001) was associated with increased EAT.

Conclusions: The presence of NAFPD on TUS is associated with increased aIMT and EAT. Our study results may suggest that NAFPD may reflect subclinical atherosclerosis and may be a simple warning sign for physicians.

Keywords: Atherosclerosis; Epicardial adipose tissue; Intima-media thickness; Non-alcoholic fatty pancreatic disease.

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Figures

Figure 1
Figure 1
(A) Arrow shows non-alcoholic fatty pancreatic disease (NAFPD). (B) Arrow shows normal pancreas.
Figure 2
Figure 2
(A) Measurement of aortic intima-media thickness (aIMT) by transabdominal ultrasonography. (B) Measurement of epicardial adipose tissue (EAT) by transthorasic echocardiography.
Figure 3
Figure 3
(A) EAT thickness in with and without non-alcoholic fatty pancreatic disease (NAFPD) subjects. (B) Aortic intima-media thickness (aIMT) in with and without NAFPD subjects.
See this image and copyright information in PMC

References

    1. Della Corte C, Mosca A, Majo F, et al. Nonalcoholic fatty pancreas disease and nonalcoholic fatty liver disease: more than ectopic fat. Clin Endocrinol (Oxf) 2015;83:656–662. - PubMed
    1. Targher G, Bertolini L, Poli F, et al. Nonalcoholic fatty liver disease and risk of future cardiovascular events among type 2 diabetic patients. Diabetes. 2005;54:3541–3546. - PubMed
    1. Kocaman SA, Baysan O, Çetin M, et al. An increase in epicardial adipose tissue is strongly associated with carotid intima-media thickness and atherosclerotic plaque, but LDL only with the plaque. Anatol J Cardiol. 2017;17:56–63. - PMC - PubMed
    1. Rohani M, Jogestrand T, Ekberg M, et al. Interrelation between the extent of atherosclerosis in the thoracic aorta, carotid intima-media thickness and the extent of coronary artery disease. Atherosclerosis. 2005;179:311–316. - PubMed
    1. Harrington J, Pena AS, Gent R, et al. Aortic intima media thickness is an early marker of atherosclerosis in children with type 1 diabetes mellitus. J Pediatr. 2010;156:237–241. - PubMed

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