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. 2019 Apr 1;5(1):14.
doi: 10.1186/s40729-019-0166-6.

PRGF as adjunct to DBB in maxillary sinus floor augmentation: histological results of a pilot split-mouth study

Leonidas Batas  1 , Lazaros Tsalikis  2 , Andreas Stavropoulos  3   4   5
Affiliations

PRGF as adjunct to DBB in maxillary sinus floor augmentation: histological results of a pilot split-mouth study

Leonidas Batas et al. Int J Implant Dent. .

Abstract

Background: Various technologies of autologous blood concentrates are currently evaluated for their potential to enhance bone formation.

Aim: To report on the histological outcome of maxillary sinus floor augmentation (MSFA) with deproteinized bovine bone (DBB) in combination with chair-side prepared autologous platelet-rich growth factor (PRGF), in comparison to that with DBB alone.

Materials and methods: Six partially edentulous patients with ≤ 3-mm residual bone height bilaterally in the posterior maxilla were subjected to MSFA with the lateral window technique, using DBB in combination with PRGF (PRGF System1 Vitoria, Spain) on one side or DBB alone on the contralateral side. Cylindrical biopsies from the augmented sinuses were collected during implant installation, ca. 6 months post-MSFA, and subjected to non-decalcified histological and histomorphometric evaluation.

Results: The collected biopsies varied in length (range 3.5-9.9 mm); consequently, the portion of the biopsy representing augmented tissues also varied (range 2.3-14.6 mm2). New bone formation with a trabecular appearance and numerous DBB particles in contact with the new bone or with loose connective tissue were observed. No differences in the relative volumes of bone formation were found in sinuses augmented with DBB + PRGF or DBB alone 6 months after MSFA (35.6 ± 8.26 mm and 37.8 ± 3.15 mm, respectively).

Conclusion and clinical implications: In conclusion, based on these preliminary results, PRGF as adjunct to DBB for MSFA, except from improved handling during the operation, does not appear to enhance nor interfere with bone formation inside the human sinus 6 months after MSFA, compared with the use of DBB alone.

Keywords: Deproteinized bovine bone; Histology; Humans; PRGF; Sinus elevation.

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Conflict of interest statement

Ethics approval and consent to participate

Patient recruitment and data collection of this study took place at the Aristotle University of Thessaloniki, School of Dentistry, Greece. The research was approved by the Ethics Committee of the Aristotle University of Thessaloniki, Greece (14/02-02-2017) and all activities were conducted in full accordance with ethical principles, including the World Medical Association Declaration of Helsinki. We described the purpose of the study to patients, and the data were obtained anonymously.

Consent for publication

Not applicable.

Competing interests

Authors Batas Leonidas, Tsalikis Lazaros, and Stavropoulos Andreas declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Panoramic radiograph (a) of one patient receiving bi-lateral MSFA with the lateral window approach (b), where after sinus membrane elevation (c), one site was grafted with DBB + PRGF (d) and the other with DBB alone (e); the window was always covered with a collagen membrane
Fig. 2
Fig. 2
PRGF is mixed with DBB (a) and after a few minutes the mixture attains a viscous consistency facilitating easy handling of the bone substitute particles (b)
Fig. 3
Fig. 3
Panoramic X-ray of the case presented in Fig. 2, 6 months post-operatively (a), showing increased radio-opacity in both grafted sinuses. Biopsies were obtained with trephine burs during oral implant site preparation (b)
Fig. 4
Fig. 4
The margin of pristine bone and augmented tissues was identified, and the various tissue components within the augmented area were semi-automatically estimated by dedicated image analysis software. Newly formed bone, connective tissue, DBB, within the augmented area, were identified and calculated
See this image and copyright information in PMC

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