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. 2019 Aug;49(8):881-889.
doi: 10.1111/hepr.13342. Epub 2019 Apr 29.

Increase trend in the prevalence and male-to-female ratio of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in Japan

Atsushi Tanaka  1 , Mitsuru Mori  2 , Kosuke Matsumoto  1 , Hiromasa Ohira  3 , Susumu Tazuma  4 , Hajime Takikawa  5
Affiliations

Increase trend in the prevalence and male-to-female ratio of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in Japan

Atsushi Tanaka et al. Hepatol Res. 2019 Aug.

Abstract

Aim: Autoimmune liver diseases (AILD) including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) impose a significant burden on public health, and it is important to estimate their prevalence. We carried out a nationwide, hospital-based, epidemiological survey of AIH, PBC, and PSC, and compared the results with those from previous surveys.

Method: We randomly selected health-care facilities used in the survey from a list of all facilities in Japan. The selection rate was determined according to a stratification based on the facility characteristics and scale. We sent questionnaires to the selected facilities enquiring about the number and sex of patients with AILD who visited the facility in 2016. An identical survey was undertaken for AIH/PBC in 2004 and for PSC in 2007; we carried out a comparative analysis of these data.

Results: We selected 1793 departments from health centers all over Japan. Of them, 1078 (60.1%) responded to the questionnaires. The number of reported patients with AIH, PBC, and PSC was 8505, 10 847, and 906, respectively, and point prevalence was 23.9 (95% confidence interval, 23.3-24.5) for AIH (8.7 in 2004), 33.8 (33.0-34.6) for PBC (11.6 in 2004), and 1.80 (1.75-1.85) for PSC (0.95 in 2007) per 100 000 population. Male-to-female patient ratio of AILD was 1:4.3 for AIH (1:6.9 in 2004), 1:3.9 for PBC (1:7.1 in 2004), and 1:0.88 for PSC (1:1.4 in 2007).

Conclusion: The current study indicates an increasing trend of prevalence as well as male-to-female patient ratio of AILD in Japan.

Keywords: autoimmune hepatitis; epidemiology; etiology; prevalence; primary biliary cholangitis; primary sclerosing cholangitis.

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References

    1. European Association for the Study of the Liver; European Association for the Study of the Liver. EASL Clinical Practice Guidelines: the diagnosis and management of patients with primary biliary cholangitis. J Hepatol 2017; 67: 145-172.
    1. Lleo A, Marzorati S, Anaya JM, Gershwin ME. Primary biliary cholangitis: a comprehensive overview. Hepatol Int 2017; 11: 485-499.
    1. Dyson JK, Beuers U, Jones DEJ, Lohse AW, Hudson M. Primary sclerosing cholangitis. Lancet 2018; 391: 2547-2559.
    1. Dyson JK, Wilkinson N, Jopson L et al. The inter-relationship of symptom severity and quality of life in 2055 patients with primary biliary cholangitis. Aliment Pharmacol Ther 2016; 44: 1039-1050.
    1. Sogo T, Takahashi A, Inui A, Fujisawa T, Ohira H, Takikawa H. Clinical features of pediatric autoimmune hepatitis in Japan: a nationwide survey. Hepatol Res 2018; 48: 286-294.

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