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. 1986 Sep 29;206(1):69-72.
doi: 10.1016/0014-5793(86)81342-4.

Isolation and structure of the Streptococcus faecalis sex pheromone, cAM373

M Mori, H Tanaka, Y Sakagami, A Isogai, M Fujino, C Kitada, B A White, F Y An, D B Clewell, A Suzuki
Free article

Isolation and structure of the Streptococcus faecalis sex pheromone, cAM373

M Mori et al. FEBS Lett. .
Free article

Abstract

The Streptococcus faecalis sex pheromone, cAM373, which induces a mating response of donor cells harboring plasmid pAM373 and is also produced by Staphylococcus aureus, was isolated and its structure determined. Supernatant from an overnight culture of a recipient strain was subjected to successive purification procedures, and 4.4 micrograms cAM373 was obtained. The isolated pheromone showed activity at a concentration as low as 5 X 10(-11) M. Sequence analysis indicated that cAM373 was a heptapeptide, H-Ala-Ile-Phe-Ile-Leu-Ala-Ser-OH, and that its Mr was 733. A synthetic replicate of the peptide showed the same biological activity and chromatographic behavior as the native cAM373.

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