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Case Reports
. 2021 Sep 1;15(5):495-499.
doi: 10.1097/ICB.0000000000000866.

INVOLUTION OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION AFTER ENDOPHTHALMITIS

Gregg T Kokame  1   2   3   4   5 , Nicolas A Yannuzzi  6 , Jessica G Shantha  2   3   4   7 , Maya Yamane  8 , Nidhi Relhan  6 , Jeffrey Gross  9 , Edwin H Ryan  10 , Harry W Flynn Jr  6
Affiliations
Case Reports

INVOLUTION OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION AFTER ENDOPHTHALMITIS

Gregg T Kokame et al. Retin Cases Brief Rep. .

Abstract

Purpose: To report patients who demonstrated an alteration in the clinical and optical coherence tomography features of neovascular age-related macular degeneration after resolution of endophthalmitis.

Methods: Retrospective case series of the subsequent changes in the macula and need for anti-vascular endothelial growth factor therapy in patients with neovascular age-related macular degeneration who developed endophthalmitis after intravitreal injection.

Results: The study included seven eyes of seven patients with follow-up ranging between 3 months and 11 years. The vitreous cultures (n = 7) before intravitreal antibiotic injection were the following: culture-negative (4) and coagulase-negative Staphylococcus (3). Initial treatment included vitreous tap and injection (4) and pars plana vitrectomy (3). In 5/7 eyes, the optical coherence tomography showed resolution of subretinal fluid and serous pigment epithelial detachment, and there was no additional anti-vascular endothelial growth factor treatment administered.

Conclusion: After successful treatment of endophthalmitis in patients with neovascular age-related macular degeneration, there was relative involution of the maculopathy and reduced anti-vascular endothelial growth factor treatment burden in this series.

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Conflict of interest statement

Competing Interests: The authors have no competing interests pertaining to this manuscript.

Figures

Figure 1:
Figure 1:
Regression of active exudation in an 87-year-old woman in neovascular age-related macular degeneration after post-injection endophthalmitis (Case 1). A) Optical coherence tomography (OCT) of the right eye two years prior to endophthalmitis shows a hyperreflective vascular pigment epithelial detachment and intraretinal fluid as well as a small epiretinal membrane. B) OCT of the right eye 4 years after post-injection endophthalmitis shows trace subretinal and intraretinal fluid, resolution of the neovascular membrane, and atrophy.
Figure 2:
Figure 2:
Regression of choroidal neovascularization in a 72-year-old woman with a history of neovascular age-related macular degeneration (Case 3). A) Optical coherence tomography (OCT) 5 months prior to the first episode of endophthalmitis discloses a vascular pigment epithelial detachment with subretinal and intraretinal fluid. B) OCT 3 months after the first episode of endophthalmitis shows reduced intraretinal and subretinal fluid. C) OCT 20 months prior to the second episode of endophthalmitis shows a moderate pigment epithelial detachment with adjacent trace subretinal fluid. D) OCT 18 months after the second episode of endophthalmitis reveals resolved macular edema with a focal area of geographic atrophy.
See this image and copyright information in PMC

References

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