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Case Reports
. 2020 May;42(4):e251-e253.
doi: 10.1097/MPH.0000000000001461.

Infantile Pyknocytosis: An Uncommon Cause of Newborn Hemolytic Anemia

Jayme Castillo  1 , Tara E Ness  1   2 , Parth S Mehta  1   2
Affiliations
Case Reports

Infantile Pyknocytosis: An Uncommon Cause of Newborn Hemolytic Anemia

Jayme Castillo et al. J Pediatr Hematol Oncol. 2020 May.

Abstract

Infantile pyknocytosis is a rare cause of neonatal hemolytic anemia, which presents in the first few weeks of life. We report a classic case of infantile pyknocytosis that presented to our institution with rebound hyperbilirubinemia after receiving phototherapy. The infant was found to have a hemoglobin of 5.8 g/dL, requiring a total of 15 mL/kg of red blood cells (in 2 separate transfusions) before discharge. The diagnosis was ultimately made by a review of the peripheral blood smear. We review the literature and suggest pediatricians consider infantile pyknocytosis on their differential when hemolytic anemia presents in the newborn period.

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References

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