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Case Reports
. 2020 May;42(4):e235-e237.
doi: 10.1097/MPH.0000000000001435.

A Novel Deletion in the RPL5 Gene in a Lebanese Child With Diamond Blackfan Anemia Unresponsive to Steroid Treatment

Roula A Farah  1 , Lojine Kamel  2 , Noemi Roy  3 , Melanie Proven  3 , Katherine Wray  3 , Irene Roberts  3 , Marcin W Wlodarski  4
Affiliations
Case Reports

A Novel Deletion in the RPL5 Gene in a Lebanese Child With Diamond Blackfan Anemia Unresponsive to Steroid Treatment

Roula A Farah et al. J Pediatr Hematol Oncol. 2020 May.

Abstract

Diamond-Blackfan Anemia (DBA) is a rare inherited form of pure red cell aplasia that usually manifests in infancy or early childhood, and is characterized by normochromic macrocytic anemia and bone marrow erythroblastopenia. The majority of DBA cases are associated with mutations in ribosomal protein genes. Here, we describe a Lebanese girl with RPL5-mutated DBA unresponsive to steroid treatment who died from complications following late hematopoietic stem cell transplantation performed at the age of 15 years.

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References

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