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Case Reports
. 2019 Sep 13;69(7):1229-1231.
doi: 10.1093/cid/ciz074.

Emergence of Low-level Delamanid and Bedaquiline Resistance During Extremely Drug-resistant Tuberculosis Treatment

Silke Polsfuss  1 , Sabine Hofmann-Thiel  2   3 , Matthias Merker  4   5 , David Krieger  6 , Stefan Niemann  4   5 , Holger Rüssmann  1 , Nicolas Schönfeld  6 , Harald Hoffmann  2   3 , Katharina Kranzer  7   8
Affiliations
Case Reports

Emergence of Low-level Delamanid and Bedaquiline Resistance During Extremely Drug-resistant Tuberculosis Treatment

Silke Polsfuss et al. Clin Infect Dis. .

Abstract

Two new drugs, delamanid and bedaquiline, have recently been approved for treatment of multidrug-resistant and extensively drug-resistant (XDR) tuberculosis. Here, we report a case of clofazimine, bedaquiline, and low-level delamanid resistances acquired during treatment of a patient with XDR tuberculosis.

Keywords: XDR-tuberculosis; bedaquiline resistance; delamanid resistance.

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