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. 2019 Mar 27;16(7):1101.
doi: 10.3390/ijerph16071101.

Study on the Relevance of Metabolic Syndrome and Incidence of Gastric Cancer in Korea

HaiWon Yoo  1 , Hyeongsu Kim  2 , Jung-Hyun Lee  3 , Kun-Sei Lee  4 , Min-Jung Choi  5 , Hye-Ry Song  6 , Jung-Hee Cho  7 , Jin-Hyeong Kim  8
Affiliations

Study on the Relevance of Metabolic Syndrome and Incidence of Gastric Cancer in Korea

HaiWon Yoo et al. Int J Environ Res Public Health. .

Abstract

(1) Background: This study aimed to determine the relevance between stages of metabolic syndrome (MS) progression and the incidence of gastric cancer utilizing a big data cohort for the national health checkup. (2) Methods: There were 7,785,098 study subjects, and three stages of metabolic syndrome were categorized using the health checkup results from 2009. Incidence of gastric cancer was traced and observed from the date of the health insurance benefit claim in 2009 until 31 December, 2016, and Cox hazard-proportional regression was performed to determine the risk of gastric cancer incidence based on the stage of progression for metabolic syndrome. (3) Results: Hazard ratio (HR) incidence rate for the MS group was 2.31 times higher than the normal group (95% CI 2.22⁻2.40) after adjustment (Model 4). The HR incidence rate of gastric cancer for the pre-MS group was 1.08 times higher (95% CI 1.04⁻1.12) than the normal group, while the HR incidence rate of gastric cancer for the MS group was 1.26 times higher (95% CI 1.2⁻1.32). (4) Conclusions: Causal relevance observed in this study between metabolic syndrome and incidence of gastric cancer was high. Promotion and education for active responses in the general population and establishment of appropriate metabolic syndrome management systems to prevent gastric cancer are needed.

Keywords: big data; gastric cancer; metabolic syndrome; relevance.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Study design and process of selecting the population.
See this image and copyright information in PMC

References

    1. Alberti K.G., Eckel R.H., Grundy S.M., Zimmet P.Z., Cleeman J.I., Donato K.A., Fruchart J.C., James W.P., Loria C.M., Smith S.C., Jr., et al. Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120:1640–1645. doi: 10.1161/CIRCULATIONAHA.109.192644. - DOI - PubMed
    1. Lin Y., Ness-Jensen E., Hveem K., Lagergren J., Lu Y. Metabolic syndrome and esophageal and gastric cancer. Cancer Causes Control. 2015;26:1825–1834. doi: 10.1007/s10552-015-0675-4. - DOI - PubMed
    1. Cameron A.J., Shaw J.E., Zimmet P.Z. The metabolic syndrome: Prevalence in worldwide populations. Endocrinol. Metab. Clin. N. Am. 2004;33:351–375. doi: 10.1016/j.ecl.2004.03.005. - DOI - PubMed
    1. Lim S., Shin H., Song J.H., Kwak S.H., Kang S.M., Won Y.J., Choi S.H., Cho S.I., Park K.S., Lee H.K., et al. Increasing prevalence of metabolic syndrome in Korea. Diabetes Care. 2011;34:1323–1328. doi: 10.2337/dc10-2109. - DOI - PMC - PubMed
    1. Cornier M.A., Dabelea D., Hernandez T.L., Lindstrom R.C., Steig A.J., Stob N.R., Van R.E., Wang H., Eckel R.H. The metabolic syndrome. Endocr. Rev. 2008;29:777–822. doi: 10.1210/er.2008-0024. - DOI - PMC - PubMed

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