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. 2019 Mar 29;5(2):31.
doi: 10.3390/ncrna5020031.

Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129

Clarissa Pedrosa da C Gomes  1 , Bence Ágg  2 , Andrejaana Andova  3 , Serdal Arslan  4 , Andrew Baker  5 , Monika Barteková  6 , Dimitris Beis  7 , Fay Betsou  8 , Stephanie Bezzina Wettinger  9 , Branko Bugarski  10 , Gianluigi Condorelli  11 , Gustavo José Justo da Silva  12 , Sabrina Danilin  13 , David de Gonzalo-Calvo  14 , Alfonso Buil  15 , Maria Carmo-Fonseca  16 , Francisco J Enguita  16 , Kyriacos Felekkis  17 , Peter Ferdinandy  2 , Mariann Gyöngyösi  18 , Matthias Hackl  19 , Kanita Karaduzovic-Hadziabdic  20 , Jan Hellemans  21 , Stephane Heymans  22 , Markéta Hlavackova  23 , Morten Andre Hoydal  24 , Aleksandra Jankovic  25 , Amela Jusic  26 , Dimitris Kardassis  27 , Risto Kerkelä  28 , Gabriela M Kuster  29 , Päivi Lakkisto  30 , Przemyslaw Leszek  31 , Mitja Lustrek  3 , Lars Maegdefessel  32 , Fabio Martelli  33 , Susana Novella  34 , Timothy O'Brien  35 , Christos Papaneophytou  17 , Thierry Pedrazzini  36 , Florence Pinet  37 , Octavian Popescu  38 , Ines Potočnjak  39 , Emma Robinson  40 , Shlomo Sasson  41 , Markus Scholz  42 , Maya Simionescu  43 , Monika Stoll  44 , Zoltan V Varga  2 , Manlio Vinciguerra  45 , Angela Xuereb  9 , Mehmet Birhan Yilmaz  46 , Costanza Emanueli  47 , Yvan Devaux  1 , on behalf of the EU-CardioRNA COST Action (CA17129)
Affiliations

Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129

Clarissa Pedrosa da C Gomes et al. Noncoding RNA. .

Abstract

Cardiovascular disease (CVD) remains the leading cause of death worldwide and, despite continuous advances, better diagnostic and prognostic tools, as well as therapy, are needed. The human transcriptome, which is the set of all RNA produced in a cell, is much more complex than previously thought and the lack of dialogue between researchers and industrials and consensus on guidelines to generate data make it harder to compare and reproduce results. This European Cooperation in Science and Technology (COST) Action aims to accelerate the understanding of transcriptomics in CVD and further the translation of experimental data into usable applications to improve personalized medicine in this field by creating an interdisciplinary network. It aims to provide opportunities for collaboration between stakeholders from complementary backgrounds, allowing the functions of different RNAs and their interactions to be more rapidly deciphered in the cardiovascular context for translation into the clinic, thus fostering personalized medicine and meeting a current public health challenge. Thus, this Action will advance studies on cardiovascular transcriptomics, generate innovative projects, and consolidate the leadership of European research groups in the field.COST (European Cooperation in Science and Technology) is a funding organization for research and innovation networks (www.cost.eu).

Keywords: best practices and guidelines; cardiovascular disease; personalized medicine; transcriptomics; translational research.

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Conflict of interest statement

The authors declare no conflict of interest. The funders have no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Coding and non-coding RNAs in the human genome. tRNAs, transfert RNAs; rRNAs, ribosomal RNAs; ncRNAs, noncoding RNAs; miRNAs, microRNAs; siRNAs, small-interfering RNAs; snRNAs, small nuclear RNAs; snoRNAs, small nucleolar RNAs; piRNAs, piwi-interacting RNAs; linRNAs, long intergenic RNAs; eRNAs, extracellular RNAs; gsRNAs, germline small RNAs; circRNAs, circular RNAs; pRNAs, promoter-associated RNAs; mRNA, messenger RNA.
Figure 2
Figure 2
Different backgrounds of the network members and their interactions to impact cardiovascular diseases (CVD) management, thus healthcare.
Figure 3
Figure 3
Overall interrelations between the four CardioRNA working groups (WGs) created to achieve the goals described.
See this image and copyright information in PMC

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