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. 2019 Apr:133:16-19.
doi: 10.1016/j.radonc.2018.12.022. Epub 2019 Jan 12.

Reoxygenation during radiotherapy in intermediate-risk prostate cancer

Stéphane Supiot  1 , Caroline Rousseau  2 , Mélanie Dore  2 , Catherine Chèze-Le-Rest  3 , Christine Kandel-Aznar  4 , Vincent Potiron  2 , Stéphane Guerif  3 , François Paris  2 , Ludovic Ferrer  2 , Loïc Campion  2 , Philippe Meingan  5 , Grégory Delpon  2 , Mathieu Hatt  6 , Dimitris Visvikis  6
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Reoxygenation during radiotherapy in intermediate-risk prostate cancer

Stéphane Supiot et al. Radiother Oncol. 2019 Apr.

Abstract

Hypoxia is a major risk factor of prostate cancer radioresistance. We evaluated hypoxia non-invasively, using 18F-Misonidazole PET/CT prior to radiotherapy and after a dose of 20 Gy in intermediate-risk prostate cancer patients. Decreased hypoxic volumes were observed in all patients, suggesting that radiotherapy induces early prostate tumor reoxygenation.

Keywords: Dose painting radiotherapy; FAZA; IMRT; Misonidazole; Radioresistance.

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