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. 2019 Jun:123:260-264.
doi: 10.1016/j.bone.2019.03.039. Epub 2019 Mar 29.

Type 1 diabetes onset at young age is associated with compromised bone quality

Viral N Shah  1 , Prakriti Joshee  2 , Rachel Sippl  2 , Laura Pyle  2 , Tim Vigers  2 , R Dana Carpenter  3 , Wendy Kohrt  4 , Janet K Snell-Bergeon  2
Affiliations

Type 1 diabetes onset at young age is associated with compromised bone quality

Viral N Shah et al. Bone. 2019 Jun.

Abstract

Women with type 1 diabetes (T1D) are at increased risk for fracture. We studied the association of T1D and young age at T1D onset (T1D onset before 20 years) on bone structural quality. 24 postmenopausal women with T1D (mean age 60.9 years, mean T1D duration 41.7 years) and 22 age, sex- and body mass index (BMI)-matched controls underwent dual X-ray absorptiometry (DXA) measured areal bone mineral density (aBMD) at the lumbar spine, hip and distal radius. Bone mass, geometry and estimated bone strength were assessed at distal and shaft of non-dominant radius and tibia using peripheral quantitative computed tomography (pQCT). Postmenopausal women with T1D had lower trabecular volumetric bone mineral density (vBMD) (LSM ± SEM; 166.1 ± 8.2 vs 195.9 ± 8.3 mg/cm3, p = 0.02) and compressive bone strength (24.6 ± 1.8 vs 30.1 ± 1.9 mg2/mm4, p = 0.04) at the distal radius compared to controls adjusting for age, BMI and radius length. At the distal radius, patients with young onset T1D had lower total vBMD (258.7 ± 19.7 vs 350.8 ± 26.1 mg/cm3, p = 0.02) and trabecular vBMD (141.4 ± 11.6 vs 213.6 ± 15.4 mg/cm3, p = 0.003) compared to adult onset T1D patients adjusting for age, BMI and the radius length. At the tibial shaft, young onset T1D patients had larger endosteal circumference (39.1 ± 1.2 vs 32.1 ± 1.6 mm, p = 0.005) with similar periosteal circumference (67.1 ± 0.9 vs 65.1 ± 1.2 mm, p = 0.2) resulting in reduced cortical thickness (4.4 ± 0.1 vs 5.2 ± 0.1 mm, p = 0.004) compared to adult onset T1D patients adjusting for age, BMI and the tibia length. There was no difference in the lumbar spine, femoral neck, total hip and distal radius DXA-measured aBMD between subjects with T1D and controls. T1D is associated with lower trabecular vBMD at the distal radius. T1D onset before age 20 is associated with cortical bone size deficits at the tibial shaft.

Keywords: Bone health; Bone mineral density; Peripheral quantitative computed tomography; Postmenopausal women; Type 1 diabetes.

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References

    1. Shah VN, Shah CS, Snell-Bergeon JK, Type 1 diabetes and risk of fracture: metaanalysis and review of the literature, Diabet. Med 32 (9) (2015) 1134–1142. - PMC - PubMed
    1. Shah VN, Carpenter RD, Ferguson VL, Schwartz AV, Bone health in type 1 diabetes, Curr. Opin. Endocrinol. Diabetes Obes 25 (4) (2018) 231–236. August. - PMC - PubMed
    1. Hothersall EJ, Livingstone SJ, Looker HC et al. Contemporary risk of hip fracture in type 1 and type 2 diabetes: a national registry study from Scotland. J. Bone Miner. Res 2014; 29:1054–60. - PMC - PubMed
    1. Shah VN, Harrall KK, Shah CS, et al., Bone mineral density at femoral neck and lumbar spine in adults with type 1 diabetes: a meta-analysis and review of the literature, Osteoporos. Int 28 (9) (2017) 2601–2610. - PubMed
    1. Rakic V, Davis WA, Chubb SA, Islam FM, Prince RL, Davis TM, Bone mineral density and its determinants in diabetes: the Fremantle Diabetes Study, Diabetologia 49 (5) (2006) 863–871 May. - PubMed

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