Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Dec 20:10.1038/d41573-018-00010-7.
doi: 10.1038/d41573-018-00010-7. Online ahead of print.

Discovering translational biomarkers in neurodevelopmental disorders

Mustafa Sahin, Stephanie R Jones, John A Sweeney, Elizabeth Berry-Kravis, Barry W Connors, Joshua B Ewen, Adam L Hartman, April R Levin, William Z Potter, Laura A Mamounas

Discovering translational biomarkers in neurodevelopmental disorders

Mustafa Sahin et al. Nat Rev Drug Discov. .

Abstract

Investment in drug development for neurodevelopmental disorders has suffered from recent failures in clinical trials that were based on promising preclinical findings. Here, we discuss development and validation of translational biomarkers of neurodevelopmental disorders that can enable more informative clinical experiments and translational success in these diseases.

PubMed Disclaimer

Conflict of interest statement

Competing interests

The authors declare competing interests: see Supplementary information.

References

    1. Krueger DA et al. Everolimus for treatment of tuberous sclerosis complex-associated neuropsychiatric disorders. Ann. Clin. Transl Neurol 4, 877–887 (2017). - PMC - PubMed
    1. Berry-Kravis EM et al. Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome. Nat. Rev. Drug Discov 17, 280–299 (2018). - PMC - PubMed
    1. Emerson RW et al. Functional neuroimaging of high-risk 6-month-old infants predicts a diagnosis of autism at 24 months of age. Sci. Transl Med 9, eaag2882 (2017). - PMC - PubMed
    1. LeBlanc JJ et al. Visual evoked potentials detect cortical processing deficits in Rett syndrome. Ann. Neurol 78, 775–786 (2015). - PMC - PubMed
    1. Ethridge LE et al. Neural synchronization deficits linked to cortical hyper-excitability and auditory hypersensitivity in fragile X syndrome. Mol. Autism 8, 22 (2017). - PMC - PubMed