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Case Reports
. 2019 Mar;44(2):163-167.

Primary Clear Cell Carcinoma with no Diethylstilbestrol Exposure; Case Series

Malihe Hasanzadeh  1 , Amir Hussein Jafarian  2 , Leila Mousavi Seresht  3
Affiliations
Case Reports

Primary Clear Cell Carcinoma with no Diethylstilbestrol Exposure; Case Series

Malihe Hasanzadeh et al. Iran J Med Sci. 2019 Mar.

Abstract

One of the rare neoplasms of cervix uteri and vagina is clear cell carcinoma; mostly in patients with a positive past medical history of intrauterine diethylstilbestrol (DES) exposure which reveals the importance of other unknown risk factors of gynecologic neoplasms. 2 Asian women referred to the gynecology-oncology department. The first one came with a complaint of prolonged vaginal discharge and the second one with irregular bleeding. Neither did report a history of DES-exposure. On vaginal examination, it was found that both cases had mass which biopsied for histologic study. They were diagnosed with primary Clear Cell Carcinoma of Vagina in the first case and Cervix uteri in the other one. Both patients underwent cytoreductive surgery soon after diagnosis.

Keywords: Cervix uteri; Diethylstilbestrol; Vagina; Clear cell adenocarcinoma.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure1
Figure1
Sagittal view of Pelvic MRI showed vaginal fornix expansion probably due to mass in the lateral of the cervix which had expanded the vagina without cervical and parametrial extension.
Figure2
Figure2
CCC of vagina showed invasive carcinoma with tubulopapillary architecture, hobnail nuclei cell (The red arrow), and Clear cells (The blue arrow). (H&Ex100& ×400)
Figure3
Figure3
A) Clear cell carcinoma of cervix showed infiltrative tubulopapillary carcinoma with eosinophilic cytoplasm with hobnail nuclei. (H&Ex100 & ×400) B) Immunohistochemical staining showed diffuse Napsin A (top) and CK7 (bottom) staining of tumor cell. (×100)
See this image and copyright information in PMC

References

    1. Tantitamit T, Hamontri S, Rangsiratanakul L. Clear cell adenocarcinoma of the cervix in second generation young women who are without maternal exposure to diethylstilbestrol: A case report. Gynecol Oncol Rep. 2017;20:34–6. doi: 10.1016/j.gore.2017.02.008. [ PMC Free Article] - DOI - PMC - PubMed
    1. Jiang X, Jin Y, Li Y, Huang HF, Wu M, Shen K, et al. Clear cell carcinoma of the uterine cervix: clinical characteristics and feasibility of fertility-preserving treatment. Onco Targets Ther. 2014;7:111–6. doi: 10.2147/OTT.S53204. [ PMC Free Article] - DOI - PMC - PubMed
    1. Ramesh K, S AS, P S, Desai RM, K A. Clear Cell Carcinoma of Cervix in a 60- year-old Woman: A Case Report. J Clin Diagn Res. 2014;8:OD01–2. doi: 10.7860/JCDR/2014/8428.4654. [ PMC Free Article] - DOI - PMC - PubMed
    1. Thomas MB, Wright JD, Leiser AL, Chi DS, Mutch DG, Podratz KC, et al. Clear cell carcinoma of the cervix: a multi-institutional review in the post-DES era. Gynecol Oncol. 2008;109:335–9. doi: 10.1016/j.ygyno.2008.02.007. [ PMC Free Article] - DOI - PMC - PubMed
    1. Garg MM, Arora VK. Clear cell adenosquamous carcinoma of the cervix: a case report with discussion of the differential diagnosis. Int J Gynecol Pathol. 2012;31:294–6. doi: 10.1097/PGP.0b013e31823b6f37. - DOI - PubMed

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