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Comment
. 2019 Mar 22:4:6.
doi: 10.1038/s41392-019-0039-8. eCollection 2019.

Deletion of the RNA-editing enzyme ADAR1A: new strategy to potentiate responses to PD-1 immune checkpoint blockade

Manni Wang  1 , Xiawei Wei  1
Affiliations
Comment

Deletion of the RNA-editing enzyme ADAR1A: new strategy to potentiate responses to PD-1 immune checkpoint blockade

Manni Wang et al. Signal Transduct Target Ther. .
No abstract available

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Figures

Fig. 1
Fig. 1
The proposed model for ADAR1 deletion to increases the sensitivity to ICBs
See this image and copyright information in PMC

Comment on

  • Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade.
    Ishizuka JJ, Manguso RT, Cheruiyot CK, Bi K, Panda A, Iracheta-Vellve A, Miller BC, Du PP, Yates KB, Dubrot J, Buchumenski I, Comstock DE, Brown FD, Ayer A, Kohnle IC, Pope HW, Zimmer MD, Sen DR, Lane-Reticker SK, Robitschek EJ, Griffin GK, Collins NB, Long AH, Doench JG, Kozono D, Levanon EY, Haining WN. Ishizuka JJ, et al. Nature. 2019 Jan;565(7737):43-48. doi: 10.1038/s41586-018-0768-9. Epub 2018 Dec 17. Nature. 2019. PMID: 30559380 Free PMC article.

References

    1. Ishizuka JJ, et al. Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade. Nature. 2019;565:43–48. doi: 10.1038/s41586-018-0768-9. - DOI - PMC - PubMed
    1. Escors D, et al. The intracellular signalosome of PD-L1 in cancer cells. Signal Transduct. Target Ther. 2018;3:26. doi: 10.1038/s41392-018-0022-9. - DOI - PMC - PubMed
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    1. Hartner JC, Walkley CR, Lu J, Orkin SH. ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. Nat. Immunol. 2009;10:109–115. doi: 10.1038/ni.1680. - DOI - PMC - PubMed
    1. Chung H, et al. Human ADAR1 prevents endogenous RNA from triggering translational shutdown. Cell. 2018;172:811–824 e814. doi: 10.1016/j.cell.2017.12.038. - DOI - PMC - PubMed

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