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. 2018 Jul;3(3):222-225.
doi: 10.1177/2380084418770662. Epub 2018 Apr 12.

Task Force on Design and Analysis in Oral Health Research: Medication-Related Osteonecrosis of the Jaw

S Ruggiero  1   2   3 , D Saxena  4 , S Tetradis  5 , T Aghaloo  6 , E Ioannidou  7   8
Affiliations

Task Force on Design and Analysis in Oral Health Research: Medication-Related Osteonecrosis of the Jaw

S Ruggiero et al. JDR Clin Trans Res. 2018 Jul.

Abstract

Knowledge Transfer Statement: This article discusses the proceedings of the conference organized by the Task Force on Design and Analysis in Oral Health Research on the understanding of the translational evidence on the etiology and pathogenesis of medication-related osteonecrosis of the jaw as well as the clinical protocols on patient management.

Keywords: MRONJ pathophysiology; MRONJ therapy; antiresorptive; bisphosphonates; microbiome; osteonecrosis of the jaws.

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Conflict of interest statement

S. Tetradis and T. Aghaloo have served as paid consultants for and have received grant support from Amgen Inc. The authors declare no other potential conflicts of interest with respect to the authorship and/or publication of this article.

References

    1. Aghaloo T, Hazboun R, Tetradis S. 2015. Pathophysiology of osteonecrosis of the jaws. Oral Maxillofac Surg Clin North Am. 27(4):489–496. - PMC - PubMed
    1. de Molon RS, Cheong S, Bezouglaia O, Dry SM, Pirih F, Cirelli JA, Aghaloo TL, Tetradis S. 2014. Spontaneous osteonecrosis of the jaws in the maxilla of mice on antiresorptive treatment: a novel ONJ mouse model. Bone. 68:11–19. - PMC - PubMed
    1. Kang B, Cheong S, Chaichanasakul T, Bezouglaia O, Atti E, Dry SM, Pirih FQ, Aghaloo TL, Tetradis S. 2013. Periapical disease and bisphosphonates induce osteonecrosis of the jaws in mice. J Bone Miner Res. 28(7):1631–1640. - PMC - PubMed
    1. Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O’Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, et al. 2015. Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res. 30(1):3–23. - PubMed
    1. Pushalkar S, Li X, Kurago Z, Ramanathapuram LV, Matsumura S, Fleisher KE, Glickman R, Yan W, Li Y, Saxena D. 2014. Oral microbiota and host innate immune response in bisphosphonate-related osteonecrosis of the jaw. Int J Oral Sci. 6(4):219–226. - PMC - PubMed

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