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Comment
. 2019 May 20;37(15):1354-1355.
doi: 10.1200/JCO.18.01768. Epub 2019 Apr 2.

Beneficial Effect of Adjuvant Dabrafenib Plus Trametinib on Recurrence-Free Survival in Patients With Resected BRAFV600-Mutant Stage III Melanoma Seems to be Short-Lived

Kenneth R Hess  1
Affiliations
Comment

Beneficial Effect of Adjuvant Dabrafenib Plus Trametinib on Recurrence-Free Survival in Patients With Resected BRAFV600-Mutant Stage III Melanoma Seems to be Short-Lived

Kenneth R Hess. J Clin Oncol. .
No abstract available

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Figures

FIG 1.
FIG 1.
Hazard ratio function estimate.
FIG 2.
FIG 2.
Hazard function estimates by treatment arm.
See this image and copyright information in PMC

Comment in

  • Reply to E. Hindié and K.R. Hess.
    Long GV, Dummer R, Schadendorf D, Santinami M, Atkinson V, Mandalà M, Chiarion-Sileni V, Larkin J, Nyakas M, Dutriaux C, Haydon A, Robert C, Mortier L, Schachter J, Lesimple T, Plummer R, Dasgupta K, Haas T, Shilkrut M, Gasal E, Kefford R, Kirkwood JM, Hauschild A. Long GV, et al. J Clin Oncol. 2019 May 20;37(15):1356-1358. doi: 10.1200/JCO.19.00004. Epub 2019 Apr 2. J Clin Oncol. 2019. PMID: 30939092 No abstract available.

Comment on

References

    1. Hauschild A, Dummer R, Schadendorf D, et al. Longer follow-up confirms relapse-free survival benefit with adjuvant dabrafenib plus trametinib in patients with resected BRAFV600–mutant stage III melanoma. J Clin Oncol. 2018;36:3441–3449. - PMC - PubMed
    1. Guyot P, Ades AE, Ouwens MJ, et al. Enhanced secondary analysis of survival data: Reconstructing the data from published Kaplan-Meier survival curves. BMC Med Res Methodol. 2012;12:9. - PMC - PubMed
    1. Hess KR. Graphical methods for assessing violations of the proportional hazards assumption in Cox regression. Stat Med. 1995;14:1707–1723. PMID: 7481205. - PubMed
    1. Hess KR, Levin VA. Getting more out of survival data by using the hazard function. Clin Cancer Res. 2014;20:1404–1409. PMID: 24501392. - PubMed