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Comment
. 2019 Jan:42:e13.
doi: 10.1017/S0140525X1800105X.

Therapy and prevention for mental health: What if mental diseases are mostly not brain disorders?

John P A Ioannidis  1
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Comment

Therapy and prevention for mental health: What if mental diseases are mostly not brain disorders?

John P A Ioannidis. Behav Brain Sci. 2019 Jan.

Abstract

Neurobiology-based interventions for mental diseases and searches for useful biomarkers of treatment response have largely failed. Clinical trials should assess interventions related to environmental and social stressors, with long-term follow-up; social rather than biological endpoints; personalized outcomes; and suitable cluster, adaptive, and n-of-1 designs. Labor, education, financial, and other social/political decisions should be evaluated for their impacts on mental disease.

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  • Reductionism in retreat.
    Borsboom D, Cramer AOJ, Kalis A. Borsboom D, et al. Behav Brain Sci. 2019 Jan;42:e32. doi: 10.1017/S0140525X18002091. Behav Brain Sci. 2019. PMID: 30940245

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