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Review
. 2019 Jun;48(3):192-196.
doi: 10.1111/jmp.12410. Epub 2019 Apr 2.

Cutaneous epitheliotropic lymphoma in a baboon (Papio spp.): A case report and a brief literature review

Elvira Carias  1   2 , Megan DeLorenzo  1   3 , Michael Owston  4 , Olga Gonzalez  1 , Shyamesh Kumar  1 , Edward J Dick Jr  1
Affiliations
Review

Cutaneous epitheliotropic lymphoma in a baboon (Papio spp.): A case report and a brief literature review

Elvira Carias et al. J Med Primatol. 2019 Jun.

Abstract

Cutaneous epitheliotropic lymphoma (CEL) has not been reported in non-human primates. We report the first case of CEL in a 9-year-old baboon. The phenotype of the neoplastic cells in this baboon is similar to CEL in humans (CD3+, CD4+, CD8-) and different from dogs (CD3+, CD4-, CD8+).

Keywords: T-lymphocytes; monkey; mycoses fungoides; primate; skin.

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Figures

Figure 1.
Figure 1.
A-I. Cutaneous epitheliotropic lymphoma in a baboon. A) Skin. Neoplasm composed of sheets of round cells consistent with intermediate-sized lymphocytes with distinct cell borders, oval to indented nuclei with dense to coarsely stippled chromatin. H&E. B) Rare areas of lymphocytes infiltrating the epidermis. H&E. C) Scattered eosinophils are present admixed with the neoplastic cells. H&E. D) Immunohistochemistry for CD3. Over 90% of the neoplastic cells are CD3+. DAB. E) Immunohistochemistry for CD3. Note the tropism to epidermis and adnexal structures (hair follicle epithelium). DAB. F) Immunohistochemistry for CD3. Note hair follicles surrounded and infiltrated by neoplastic cells. DAB. G) Immunohistochemistry for CD4. Over 90% of the neoplastic cells are CD4+. DAB. H) Immunohistochemistry for CD20. Note clusters of few (less than 5%) CD20+ lymphocytes. DAB. Inset: Higher magnification of CD20+ cells. I) Immunohistochemistry for CD68. Note few (less than 5%) CD68+ macrophages. DAB. Inset: Higher magnification of CD68+ cells.
See this image and copyright information in PMC

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References

    1. Fontaine J, Heimann M, Day MJ: Cutaneous epitheliotropic T-cell lymphoma in the cat: a review of the literature and five new cases. Veterinary Dermatology 2011; 22:454–461. - PubMed
    1. Mineshige T, Kawarai S, Yauchi T, Segawa K, Neo S, Sugahara G, Kamiie J, Hisasue M, Shirota K: Cutaneous epitheliotropic T-cell lymphoma with systemic dissemination in a dog. Journal of Veterinary Diagnostic Investigation 2016; 28:327–331. - PubMed
    1. Neta M, Naigamwalla D, Bienzle D: Perforin Expression in Feline Epitheliotropic Cutaneous Lymphoma. Journal of Veterinary Diagnostic Investigation 2008; 20:831–835. - PubMed
    1. Taylor BF, Bekkevold CM, Aguirre JI, Andrutis K, Reinhard MK: Cutaneous Epitheliotropic T-Cell Lymphoma in a Marsh Rice Rat (Oryzomys palustris). Comp Med 2015; 65:416–419. - PMC - PubMed
    1. Prats M, Fondevila D, Rabanal RM, Marco A, Domingo M, Ferrer L: Epidermotropic Cutaneous Lymphoma (Mycosis Fungoides) in an SD Rat. Veterinary Pathology 1994; 31:396–398. - PubMed