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. 1986 Sep-Oct;26(5):481-3.
doi: 10.1046/j.1537-2995.1986.26587020131.x.

Inactivation of human T-cell lymphotropic virus, type III by heat, chemicals, and irradiation

G V Quinnan Jr, M A Wells, A E Wittek, M A Phelan, R E Mayner, S Feinstone, R H Purcell, J S Epstein

Inactivation of human T-cell lymphotropic virus, type III by heat, chemicals, and irradiation

G V Quinnan Jr et al. Transfusion. 1986 Sep-Oct.

Abstract

Infectivity of human T-cell lymphotropic virus, Type III (HTLV-III) was inactivated by heat more rapidly if in liquid medium than if lyophilized and more rapidly at 60 degrees than 56 degrees C. When HTLV-III was added to factor VIII suspension, then lyophilized and heated at 60 degrees C for 2 hours or longer there was elimination of 1 X 10(6) in vitro infectious units (IVIU) of virus. Much of the viral inactivation appeared to result from lyophilization. The application of water-saturated chloroform to the lyophilized material containing virus also resulted in elimination of infectivity. HTLV-III was efficiently inactivated by formalin, beta-propiolactone, ethyl ether, detergent, and ultraviolet light plus psoralen. The results are reassuring regarding the potential safety of various biological products.

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