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Comment
. 2019 Apr 2;29(4):790-792.
doi: 10.1016/j.cmet.2019.03.007.

Fatty Acid Desaturation Gets a NAD+ Reputation

Andrew J Lutkewitte  1 , Shawn C Burgess  2 , Brian N Finck  3
Affiliations
Comment

Fatty Acid Desaturation Gets a NAD+ Reputation

Andrew J Lutkewitte et al. Cell Metab. .

Abstract

delta-5 desaturase and delta-6 desaturase are enzymes known to be involved in the synthesis of highly unsaturated fatty acids. In this issue, Kim et al. (2019) show that production of NAD+ by this desaturase reaction is an adaptive response to NAD+ depletion that may regulate cellular REDOX status.

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Conflict of interest statement

DECLARATION OF INTERESTS

B.N.F. is a shareholder and member of the Scientific Advisory Board of Cirius Therapeutics.

Figures

Figure 1.
Figure 1.. Desaturases in the Regulation of NAD Homeostasis and HUFA Biosynthesis
A schematic depicting the activation of D5D/D6D enzymes by metabolic stress, the compensatory responses, and the remaining mechanistic questions is shown.
See this image and copyright information in PMC

Comment on

References

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