Vascular Organoids: Are We Entering a New Area of Cardiometabolic Research?

Tyler T Cooper¹, David A Hess², Subodh Verma³

Affiliations

¹ Robarts Research Institute, Western University, London, ON, Canada; Department of Physiology and Pharmacology, Western University, London, ON, Canada.
² Robarts Research Institute, Western University, London, ON, Canada; Department of Physiology and Pharmacology, Western University, London, ON, Canada; Division of Vascular Surgery, St Michael's Hospital, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. Electronic address: dhess@robarts.ca.
³ Division of Cardiac Surgery, St Michael's Hospital, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Department of Surgery, University of Toronto, Toronto, ON, Canada.

PMID: 30943391
DOI: 10.1016/j.cmet.2019.03.008

Free article

Comment

Vascular Organoids: Are We Entering a New Area of Cardiometabolic Research?

Tyler T Cooper et al. Cell Metab. 2019.

Free article

. 2019 Apr 2;29(4):792-794.

doi: 10.1016/j.cmet.2019.03.008.

Authors

Tyler T Cooper¹, David A Hess², Subodh Verma³

Affiliations

¹ Robarts Research Institute, Western University, London, ON, Canada; Department of Physiology and Pharmacology, Western University, London, ON, Canada.
² Robarts Research Institute, Western University, London, ON, Canada; Department of Physiology and Pharmacology, Western University, London, ON, Canada; Division of Vascular Surgery, St Michael's Hospital, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. Electronic address: dhess@robarts.ca.
³ Division of Cardiac Surgery, St Michael's Hospital, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Department of Surgery, University of Toronto, Toronto, ON, Canada.

PMID: 30943391
DOI: 10.1016/j.cmet.2019.03.008

Abstract

Recently in Nature, Wimmer et al. (2019) reported on the development of a human organoid model of vascular development recapitulating vascular pathology during type 2 diabetes. Integration of these organoids into the vasculature of immunodeficient mice may provide cardiometabolic researchers with a "personalized" platform for novel therapeutic discovery.

PubMed Disclaimer

Comment on

Human blood vessel organoids as a model of diabetic vasculopathy.
Wimmer RA, Leopoldi A, Aichinger M, Wick N, Hantusch B, Novatchkova M, Taubenschmid J, Hämmerle M, Esk C, Bagley JA, Lindenhofer D, Chen G, Boehm M, Agu CA, Yang F, Fu B, Zuber J, Knoblich JA, Kerjaschki D, Penninger JM. Wimmer RA, et al. Nature. 2019 Jan;565(7740):505-510. doi: 10.1038/s41586-018-0858-8. Epub 2019 Jan 16. Nature. 2019. PMID: 30651639 Free PMC article.

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Vascular Organoids: Are We Entering a New Area of Cardiometabolic Research?

Affiliations

Vascular Organoids: Are We Entering a New Area of Cardiometabolic Research?

Authors

Affiliations

Abstract

Comment on

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical