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. 2020;75(3):136-143.
doi: 10.1080/19338244.2019.1577210. Epub 2019 Apr 4.

Anti-Müllerian hormone levels in nurses working night shifts

Candice Y Johnson  1 , Lauren J Tanz  2   3 , Christina C Lawson  1 , Penelope P Howards  4 , Elizabeth R Bertone-Johnson  5 , A Heather Eliassen  2   6 , Eva S Schernhammer  6   7 , Janet W Rich-Edwards  2   6   8
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Anti-Müllerian hormone levels in nurses working night shifts

Candice Y Johnson et al. Arch Environ Occup Health. 2020.

Abstract

Our objective was to examine associations between night shift work and serum anti-Müllerian hormone (AMH) levels. We analyzed 1,537 blood samples from premenopausal female nurses in the Nurses' Health Study II, assayed for AMH. Rotating or permanent night shifts worked in the two weeks before blood collection and years of rotating night shift work were obtained via questionnaire. We found no associations between recent night shifts or rotating night shift work and AMH. The median difference in AMH was 0.3 (95% CI: -0.4, 0.8) ng/mL for ≥5 versus 0 recent night shifts and -0.1 (95% CI: -0.4, 0.3) ng/mL for ≥6 versus 0 years of rotating night shift work. Although we found no associations between night shift work and AMH, this does not preclude associations between night shift work and fertility operating through other mechanisms.

Keywords: Anti-Mullerian hormone; Nurses' Health Study; nurses; ovarian reserve; shift work.

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Conflict of interest statement

CONFLICTS OF INTEREST

None declared.

Figures

Figure 1.
Figure 1.
Adjusted associations between night shift work and median AMH levels (ng/mL) with 95% confidence intervals. Upper panel, by night shifts worked in the two weeks before blood collection. Lower panel, by years of rotating night shift work. Analyses: original; restricting to non-Hispanic white nurses; restricting to timed samples; excluding AMH levels >4.7 ng/mL; excluding participants from the early menopause study; stratifying by age; and stratifying by pregnancy history.
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