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Review
. 2019 Apr 4;132(7):jcs223826.
doi: 10.1242/jcs.223826.

Survivin at a glance

Sally P Wheatley  1 , Dario C Altieri  2
Affiliations
Review

Survivin at a glance

Sally P Wheatley et al. J Cell Sci. .

Abstract

Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all cancers; consequently, it has received significant attention as a potential oncotherapeutic target. In this Cell Science at a Glance article and accompanying poster, we summarise our knowledge of survivin 21 years on from its initial discovery. We describe the structure, expression and function of survivin, highlight its interactome and conclude by describing anti-survivin strategies being trialled.

Keywords: Apoptosis; BIRC5; Cancer; Mitosis; Survivin.

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Conflict of interest statement

Competing interestsThe authors declare no competing or financial interests.

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