Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Sep 21;31(4):496-498.
doi: 10.1080/08998280.2018.1494495. eCollection 2018 Oct.

Management of bioprosthetic cardiac valve thrombosis

Affiliations
Case Reports

Management of bioprosthetic cardiac valve thrombosis

Jerry Fan et al. Proc (Bayl Univ Med Cent). .

Abstract

Valvular thrombosis is a known complication of bioprosthetic valve replacement that usually occurs within a year of implantation. Four-dimensional computed tomography is quickly becoming the gold standard to directly visualize thrombus. Current guidelines for prophylaxis include aspirin for all bioprosthetic valve replacements, dual antiplatelet therapy for aortic valves, and anticoagulation for mitral valves. However, new trials have suggested single-agent antiplatelet therapy or anticoagulation for treatment of bioprosthetic valve thrombosis. Three cases are presented that illustrate the use of anticoagulants and new techniques for detecting thrombosis on imaging.

Keywords: Anticoagulation; bioprosthetic valve replacement; thrombosis.

PubMed Disclaimer

References

    1. Makkar RR, Fontana G, Jilaihawi H, et al. . Possible subclinical leaflet thrombosis in bioprosthetic aortic valves. N Engl J Med. 2015;373(21):2015–2024. doi:10.1056/NEJMoa1509233. - DOI - PubMed
    1. Puri R, Auffret V, Rodés-Cabau J. Bioprosthetic valve thrombosis. J Am Coll Cardiol. 2017;69(17):2193–2211. doi:10.1016/j.jacc.2017.02.051. - DOI - PubMed
    1. Córdoba-Soriano JG, Puri R, Amat-Santos I, et al. . Valve thrombosis following transcatheter aortic valve implantation: a systematic review. Rev Esp Cardiol (Engl Ed). 2015;68(3):198–204. doi:10.1016/j.recesp.2014.10.004. - DOI - PubMed
    1. Toggweiler S, Schmidt K, Paul M, Cuculi F, Kobza R, Jamshidi P. Valve thrombosis 3 years after transcatheter aortic valve implantation. Int J Cardiol. 2016;207:122–124. doi:10.1016/j.ijcard.2016.01.080. - DOI - PubMed
    1. De Marchena E, Mesa J, Pomenti S, et al. . Thrombus formation following transcatheter aortic valve replacement. JACC Cardiovasc Interv. 2015;8(5):728–739. doi:10.1016/j.jcin.2015.03.005. - DOI - PubMed

Publication types

LinkOut - more resources