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. 2019 Winter;12(1):60-66.

Gene expression profile analysis of colon cancer grade II into grade III transition by using system biology

Mohammad Rostami-Nejad  1 , Sina Rezaei Tavirani  2 , Vahid Mansouri  2 , Somayeh Jahani-Sherafat  3 , Hamideh Moravvej Farshi  4
Affiliations

Gene expression profile analysis of colon cancer grade II into grade III transition by using system biology

Mohammad Rostami-Nejad et al. Gastroenterol Hepatol Bed Bench. 2019 Winter.

Abstract

Aim: Gene expression profile analysis of colon cancer grade II into grade III transition by using system biology.

Background: Colon cancer is one of lethal cancer in men and women. Treatment in advanced colon cancer is difficult and survival rate is low.

Methods: Gene expression profiles of children patients with non-preforated appendicitis in comparison with the samples with non- appendicitis abdominal pain are analysis via protein - protein interaction PPI and the critical compounds are introduced by STITCH.

Results: Six critical genes including MAPK3, AKT1, SRC, TP53, GAPDH, and ALB were identified as a possible biomarker panel related to colon cancer grade II to III transition. Among these critical genes roles of MAPK3, AKT1, SRC, TP53 are highlighted.

Conclusion: It was concluded that target therapy to regulate SRC and TP53 may be the effective therapeutic way to treatment of colon cancer and more researches in necessary to design drugs for these purposes.

Keywords: Colon cancer; biomarker; gene.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Box plot presentation of three gene profiles of colon cancer grade II samples (GSM615918, 31, and GSM721723) and grade III (GSM 615940, 53, and 55)
Figure 2
Figure 2
Main connected component of colon cancer grades II and III. The nodes are layout based on degree value. Color from blue to red refers to increment of degree
Figure 3
Figure 3
Degree distribution of colon cancer grades II and III network
Figure 4
Figure 4
Action map of 6 critical DEGs of colon cancer grades II and III network. Green; activation, red; inhibition, blue; binding, and yellow; expression. Arrow, bar, and round tips are corresponding to activation, inhibition (and down-regulation), and up-regulation respectively
See this image and copyright information in PMC

References

    1. Markle B, May EJ, Majumdar AP. Do nutraceutics play a role in the prevention and treatment of colorectal cancer? Cancer and Metastasis Rev. 2010;29:395–404. - PubMed
    1. Kanwar SS, Poolla A, Majumdar AP. Regulation of colon cancer recurrence and development of therapeutic strategies. World J gastrointest Pathophysiol. 2012;3:1. - PMC - PubMed
    1. Aghili M, Izadi S, Madani H, Mortazavi H. Clinical and pathological evaluation of patients with early and late recurrence of colorectal cancer. Asia Pac J Clin Oncol. 2010;6:35–41. - PubMed
    1. Yamamoto T, Hiroi A, Itagaki H, Kato Y, Iizuka B, Itabashi M, et al. Well-differentiated adenocarcinoma associated with ulcerative colitis. SAGE Open Med Case Rep. 2017;5:2050313X17692902. - PMC - PubMed
    1. Hamzehzadeh L, Yousefi M, Ghaffari S-H. Colorectal Cancer Screening: A Comprehensive Review to Recent Non-Invasive Methods. Int J Hematol Oncol Stem Cell Res. 2017;11:250. - PMC - PubMed

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