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Comment
. 2019 Aug;61(2):136-138.
doi: 10.1165/rcmb.2019-0074ED.

Orchestrating Airway Smooth Muscle Cell Migration: GMFγ Phosphorylation Is the Key

Mark D Ihrie  1 , Jennifer L Ingram  2   3
Affiliations
Comment

Orchestrating Airway Smooth Muscle Cell Migration: GMFγ Phosphorylation Is the Key

Mark D Ihrie et al. Am J Respir Cell Mol Biol. 2019 Aug.
No abstract available

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Figures

Figure 1.
Figure 1.
During cell migration, the actin cytoskeleton undergoes reassembly and actin branch formation at the leading edge to form the lamellipodia, and new focal adhesions form (top). Phosphorylated GMFγ (glia maturation factor γ) is recruited to the leading edge, where it is associated with the Arp2/3 (actin-related protein 2/3) complex and N-WASP (neural Wiskott-Aldrich syndrome protein; middle right). Nonphosphorylated GMFγ is recruited to focal adhesions, where it associates with N-WASP, vinculin, and zyxin to promote focal adhesion assembly (middle left). Phosphorylation of GMFγ is mediated by c-Abl (ABL proto-oncogene 1). In response to external signals, c-Abl is activated and phosphorylates GMFγ, which then recruits phosphorylated N-WASP and associates with the Arp2/3 complex to promote actin branch formation. P = phosphorylated.
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