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Case Reports
. 2020 Nov;42(8):e795-e797.
doi: 10.1097/MPH.0000000000001474.

Recurrent Skin Langerhan Cell Histiocytosis Successfully Treated With Indomethacin Monotherapy

Aditi Dhir  1 , David R Kelly  2 , Raymond G Watts  3 , Matthew A Kutny  1
Affiliations
Case Reports

Recurrent Skin Langerhan Cell Histiocytosis Successfully Treated With Indomethacin Monotherapy

Aditi Dhir et al. J Pediatr Hematol Oncol. 2020 Nov.

Abstract

Langerhans cell histiocytosis (LCH) often has a recurrent and refractory course despite multiagent treatment modalities. Common relapse treatments include intense or prolonged cytotoxic chemotherapy regimens. There are a few prior reports that the nonsteroidal anti-inflammatory drug indomethacin demonstrated activity against bone LCH. Here we report indomethacin as a successful treatment for a case of chronic skin LCH that failed multiple prior chemotherapy regimens. This experience supports the need for trials to investigate indomethacin as a treatment for LCH both in the relapsed or refractory setting as well as potential combination or maintenance therapy in newly diagnosed patients.

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References

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